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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MORC3

Summary for MORC3

Gene information	Gene symbol	MORC3
	Ensembl ID	ENSG00000159256
	Entrez ID	23515
	Gene name	MORC family CW-type zinc finger 3
	Synonyms	KIAA0136\|NXP2\|ZCW5\|ZCWCC3
	Gene type	protein_coding
	UniProtAcc	Q14149

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Dataset with differentially expressed gene: MORC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.271291	3.87e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.277956	0.00e+00

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Expression of MORC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MORC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MORC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MORC3	hsa-miR-3148	99.0149	NM_001320445
MORC3	hsa-miR-144-3p	98.4673	NM_001320445
MORC3	hsa-miR-101-3p	98.4673	NM_001320445
MORC3	hsa-miR-92b-3p	97.3181	NM_001320445
MORC3	hsa-miR-25-3p	97.3181	NM_001320445
MORC3	hsa-miR-32-5p	97.3181	NM_001320445
MORC3	hsa-miR-363-3p	97.3181	NM_001320445
MORC3	hsa-miR-367-3p	97.3181	NM_001320445
MORC3	hsa-miR-92a-3p	97.3181	NM_001320445
MORC3	hsa-miR-9902	96.9813	NM_001320445
MORC3	hsa-miR-3059-3p	96.714	NM_001320446
MORC3	hsa-miR-548ai	95.8861	NM_001320446
MORC3	hsa-miR-570-5p	95.8861	NM_001320446
MORC3	hsa-miR-548ba	95.8861	NM_001320446
MORC3	hsa-miR-548ag	95.8861	NM_001320446
MORC3	hsa-miR-6124	95.4909	NM_001320445
MORC3	hsa-miR-545-5p	94.9783	NM_001320445
MORC3	hsa-miR-205-3p	94.8783	NM_001320445
MORC3	hsa-miR-4742-5p	94.0443	NM_001320446
MORC3	hsa-miR-3908	93.2082	NM_001320446
MORC3	hsa-miR-5700	89.7648	NM_001320445
MORC3	hsa-miR-3121-3p	89.7299	NM_001320445
MORC3	hsa-miR-153-3p	89.6956	NM_001320445
MORC3	hsa-miR-200a-5p	89.4129	NM_001320446
MORC3	hsa-miR-200b-5p	89.4129	NM_001320446
MORC3	hsa-miR-7852-3p	89.3682	NM_001320446
MORC3	hsa-miR-4262	89.1151	NM_001320446
MORC3	hsa-miR-8073	87.352	NM_001320446
MORC3	hsa-miR-221-5p	87.352	NM_001320446
MORC3	hsa-miR-6833-5p	87.122	NM_001320446
MORC3	hsa-miR-548m	85.6061	NM_001320446
MORC3	hsa-miR-3190-3p	85.4899	NM_001320445
MORC3	hsa-miR-548c-3p	85.1566	NM_001320445
MORC3	hsa-miR-3145-3p	84.4194	NM_001320446
MORC3	hsa-miR-12124	83.3881	NM_001320446
MORC3	hsa-miR-548aj-3p	83.0541	NM_001320445
MORC3	hsa-miR-548x-3p	83.0541	NM_001320445
MORC3	hsa-miR-513a-5p	82.4873	NM_001320446
MORC3	hsa-miR-4652-3p	82.1307	NM_001320446
MORC3	hsa-miR-218-2-3p	81.7535	NM_001320446
MORC3	hsa-miR-181a-5p	81.125	NM_001320446
MORC3	hsa-miR-181b-5p	81.125	NM_001320446
MORC3	hsa-miR-181d-5p	81.125	NM_001320446
MORC3	hsa-miR-181c-5p	81.125	NM_001320446
MORC3	hsa-miR-4729	80.9805	NM_001320445
MORC3	hsa-miR-2054	80.879	NM_001320446
MORC3	hsa-miR-95-5p	80.4543	NM_001320446

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Motifs and transcription factors (TFs) regulating MORC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MORC3	transfac_pro__M01199	TRIM28 (directAnnotation).
MORC3	hdpi__TP73	TP73 (directAnnotation).
MORC3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MORC3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MORC3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MORC3	hdpi__ELF2	ELF2 (directAnnotation).
MORC3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MORC3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MORC3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."