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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MORC1

Summary for MORC1

Gene information	Gene symbol	MORC1
	Ensembl ID	ENSG00000114487
	Entrez ID	27136
	Gene name	MORC family CW-type zinc finger 1
	Synonyms	CT33\|MORC\|ZCW6
	Gene type	protein_coding
	UniProtAcc	Q86VD1

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Dataset with differentially expressed gene: MORC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.285653	3.26e-16

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Expression of MORC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MORC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MORC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MORC1	hsa-miR-4477b	98.5882	NM_014429
MORC1	hsa-miR-3529-3p	97.5857	NM_014429
MORC1	hsa-miR-7856-5p	96.5617	NM_014429
MORC1	hsa-miR-196a-1-3p	95.7845	NM_014429
MORC1	hsa-miR-511-3p	94.2033	NM_014429
MORC1	hsa-miR-4766-5p	93.4145	NM_014429
MORC1	hsa-miR-3065-5p	90.523	NM_014429
MORC1	hsa-miR-12115	89.8835	NM_014429
MORC1	hsa-miR-153-5p	88.4524	NM_014429
MORC1	hsa-miR-4307	87.0773	NM_014429
MORC1	hsa-miR-5692a	86.9467	NM_014429
MORC1	hsa-miR-7109-5p	86.2014	NM_014429
MORC1	hsa-miR-6830-3p	84.7363	NM_014429
MORC1	hsa-miR-1236-5p	84.1768	NM_014429
MORC1	hsa-miR-126-5p	81.2394	NM_014429
MORC1	hsa-miR-4495	80.8326	NM_014429
MORC1	hsa-miR-141-5p	80.602	NM_014429

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Motifs and transcription factors (TFs) regulating MORC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MORC1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
MORC1	metacluster_141.4	GLIS2 (directAnnotation).
MORC1	jaspar__MA1483.2	ELF2 (directAnnotation).
MORC1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MORC1	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
MORC1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
MORC1	transfac_pro__M01660	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."