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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MOCS2

Summary for MOCS2

Gene information	Gene symbol	MOCS2
	Ensembl ID	ENSG00000164172
	Entrez ID	4338
	Gene name	molybdenum cofactor synthesis 2
	Synonyms	MOCO1\|MOCS2A\|MOCS2B
	Gene type	protein_coding
	UniProtAcc	O96033

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Dataset with differentially expressed gene: MOCS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.36742	3.00e-24
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.275199	2.07e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.587543	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.298257	8.41e-45
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.282965	9.37e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.271732	2.24e-44

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Expression of MOCS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOCS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MOCS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOCS2	hsa-miR-718	95.2434	NM_176806
MOCS2	hsa-miR-3119	95.2095	NM_176806
MOCS2	hsa-miR-365b-5p	92.9265	NM_004531
MOCS2	hsa-miR-365a-5p	92.9265	NM_004531
MOCS2	hsa-miR-548c-3p	92.9229	NM_176806
MOCS2	hsa-miR-4795-3p	90.1539	NM_004531
MOCS2	hsa-miR-4646-3p	89.4906	NM_004531
MOCS2	hsa-miR-4478	87.8685	NM_004531
MOCS2	hsa-miR-4433b-5p	87.5018	NM_004531
MOCS2	hsa-miR-2114-5p	86.4692	NM_176806
MOCS2	hsa-miR-95-5p	85.5274	NM_004531
MOCS2	hsa-miR-6738-3p	85.2328	NM_176806
MOCS2	hsa-miR-499a-3p	84.9567	NM_004531
MOCS2	hsa-miR-499b-3p	84.9567	NM_004531
MOCS2	hsa-miR-4433a-5p	84.8611	NM_004531
MOCS2	hsa-miR-561-3p	84.3185	NM_176806
MOCS2	hsa-miR-4677-5p	84.1498	NM_004531
MOCS2	hsa-miR-218-5p	83.7771	NM_004531
MOCS2	hsa-miR-4766-5p	83.6717	NM_176806
MOCS2	hsa-miR-3124-3p	83.5319	NM_176806
MOCS2	hsa-miR-4306	83.3561	NM_004531
MOCS2	hsa-miR-548aj-3p	82.7783	NM_176806
MOCS2	hsa-miR-548x-3p	82.7783	NM_176806
MOCS2	hsa-miR-146b-5p	82.5681	NM_004531
MOCS2	hsa-miR-146a-5p	82.5681	NM_004531
MOCS2	hsa-miR-7153-5p	82.5681	NM_004531
MOCS2	hsa-miR-551b-5p	82.096	NM_004531
MOCS2	hsa-miR-3148	81.0835	NM_004531
MOCS2	hsa-miR-3929	80.9811	NM_004531
MOCS2	hsa-miR-4727-5p	80.5238	NM_004531
MOCS2	hsa-miR-3977	80.0576	NM_176806

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Motifs and transcription factors (TFs) regulating MOCS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MOCS2	transfac_pro__M02002	MECOM; RUNX1 (directAnnotation).
MOCS2	transfac_pro__M06512	ZNF461 (directAnnotation).
MOCS2	transfac_pro__M04844	MAX (directAnnotation).
MOCS2	metacluster_161.4	LHX9 (directAnnotation).
MOCS2	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MOCS2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MOCS2	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
MOCS2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MOCS2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MOCS2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
MOCS2	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MOCS2	"Fosdenopterin"	DB16628	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."