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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MOB1B

Summary for MOB1B

Gene information	Gene symbol	MOB1B
	Ensembl ID	ENSG00000173542
	Entrez ID	92597
	Gene name	MOB kinase activator 1B
	Synonyms	MOB4A\|MOBKL1A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MOB1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.423091	3.64e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.274833	0.00e+00

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Expression of MOB1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOB1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MOB1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOB1B	hsa-miR-3662	99.5031	NM_001244766
MOB1B	hsa-miR-1277-5p	99.2953	NM_173468
MOB1B	hsa-miR-5011-5p	99.2872	NM_173468
MOB1B	hsa-miR-548aj-3p	97.9418	NM_001244766
MOB1B	hsa-miR-548x-3p	97.9418	NM_001244766
MOB1B	hsa-miR-153-5p	97.8105	NM_001244766
MOB1B	hsa-miR-590-3p	97.631	NM_173468
MOB1B	hsa-miR-3163	97.6074	NM_001244766
MOB1B	hsa-miR-548ag	97.4829	NM_173468
MOB1B	hsa-miR-548ai	97.4829	NM_173468
MOB1B	hsa-miR-548ba	97.4829	NM_173468
MOB1B	hsa-miR-570-5p	97.4829	NM_173468
MOB1B	hsa-miR-548j-3p	97.3069	NM_001244766
MOB1B	hsa-miR-548ah-3p	97.3069	NM_001244766
MOB1B	hsa-miR-548ae-3p	97.3069	NM_001244766
MOB1B	hsa-miR-548aq-3p	97.3069	NM_001244766
MOB1B	hsa-miR-548am-3p	97.3069	NM_001244766
MOB1B	hsa-miR-5692a	97.2256	NM_001244766
MOB1B	hsa-miR-3148	97.045	NM_173468
MOB1B	hsa-miR-3613-3p	97.0024	NM_001244767
MOB1B	hsa-miR-579-3p	96.7695	NM_001244766
MOB1B	hsa-miR-664b-3p	96.4177	NM_001244766
MOB1B	hsa-miR-12136	96.1016	NM_173468
MOB1B	hsa-miR-607	95.3703	NM_001244766
MOB1B	hsa-miR-5696	94.7306	NM_001244767
MOB1B	hsa-miR-3976	94.7227	NM_173468
MOB1B	hsa-miR-6875-3p	94.4846	NM_001244766
MOB1B	hsa-miR-8061	94.3143	NM_001244767
MOB1B	hsa-miR-548d-3p	93.9054	NM_173468
MOB1B	hsa-miR-4760-5p	93.8059	NM_001244767
MOB1B	hsa-miR-6513-3p	93.7932	NM_173468
MOB1B	hsa-miR-656-3p	93.6163	NM_173468
MOB1B	hsa-miR-4282	93.2623	NM_001244766
MOB1B	hsa-miR-4263	93.1959	NM_173468
MOB1B	hsa-miR-548z	93.0796	NM_173468
MOB1B	hsa-miR-548h-3p	93.0796	NM_173468
MOB1B	hsa-miR-548ac	93.0796	NM_173468
MOB1B	hsa-miR-548bb-3p	93.0796	NM_173468
MOB1B	hsa-miR-4729	92.9521	NM_001244767
MOB1B	hsa-miR-410-3p	92.8981	NM_173468
MOB1B	hsa-miR-154-3p	92.7828	NM_173468
MOB1B	hsa-miR-487a-3p	92.7828	NM_173468
MOB1B	hsa-miR-3658	92.5127	NM_173468
MOB1B	hsa-miR-513a-3p	92.4855	NM_001244766
MOB1B	hsa-miR-513c-3p	92.4855	NM_001244766
MOB1B	hsa-miR-19b-3p	92.4384	NM_001244766
MOB1B	hsa-miR-19a-3p	92.4384	NM_001244766
MOB1B	hsa-miR-4659a-3p	91.907	NM_001244766
MOB1B	hsa-miR-4659b-3p	91.907	NM_001244766
MOB1B	hsa-miR-1206	91.7976	NM_001244767

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Motifs and transcription factors (TFs) regulating MOB1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MOB1B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MOB1B	transfac_pro__M01122	ZNF219 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MOB1B	metacluster_7.13	ZFX (directAnnotation).
MOB1B	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MOB1B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MOB1B	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MOB1B	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MOB1B	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MOB1B	transfac_pro__M01253	CNOT3 (directAnnotation).
MOB1B	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MOB1B	jaspar__MA1721.1	ZNF93 (directAnnotation).
MOB1B	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MOB1B	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MOB1B	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
MOB1B	cisbp__M00341	PAX6 (directAnnotation).
MOB1B	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MOB1B	transfac_pro__M01199	TRIM28 (directAnnotation).
MOB1B	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
MOB1B	tfdimers__MD00151	CHURC1 (directAnnotation).
MOB1B	tfdimers__MD00391	KLF4 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
MOB1B	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
MOB1B	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MOB1B	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MOB1B	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
MOB1B	transfac_public__M00491	PATZ1 (directAnnotation).
MOB1B	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MOB1B	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MOB1B	transfac_pro__M06126	ZNF43 (directAnnotation).
MOB1B	metacluster_144.12	ZNF419; ZNF773 (directAnnotation).
MOB1B	transfac_pro__M06342	ZNF329 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."