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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MOB1A

Summary for MOB1A

Gene information	Gene symbol	MOB1A
	Ensembl ID	ENSG00000114978
	Entrez ID	55233
	Gene name	MOB kinase activator 1A
	Synonyms	C2orf6\|FLJ10788\|FLJ11595\|Mats1\|MOB1\|Mob4B\|MOBK1B\|MOBKL1B
	Gene type	protein_coding
	UniProtAcc	Q9H8S9

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Dataset with differentially expressed gene: MOB1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.372526	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.252799	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.277332	2.59e-40
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	cDCs	-0.29554	1.00e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.741193	1.04e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.306065	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.306807	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.576355	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.329968	2.72e-23

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Expression of MOB1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MOB1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MOB1A	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MOB1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MOB1A	hsa-miR-3613-3p	96.4031	NM_018221
MOB1A	hsa-miR-578	95.9235	NM_018221
MOB1A	hsa-miR-32-3p	95.4907	NM_001317112
MOB1A	hsa-miR-6782-3p	95.1173	NM_018221
MOB1A	hsa-miR-3133	94.446	NM_001317112
MOB1A	hsa-miR-3977	90.7071	NM_018221
MOB1A	hsa-miR-4703-5p	89.8293	NM_018221
MOB1A	hsa-miR-3908	89.5918	NM_018221
MOB1A	hsa-miR-2861	89.1267	NM_018221
MOB1A	hsa-miR-186-5p	88.3011	NM_001317112
MOB1A	hsa-miR-371b-5p	87.715	NM_001317112
MOB1A	hsa-miR-373-5p	87.715	NM_001317112
MOB1A	hsa-miR-616-5p	87.715	NM_001317112
MOB1A	hsa-miR-12124	86.3297	NM_018221
MOB1A	hsa-miR-29a-3p	85.9755	NM_001317112
MOB1A	hsa-miR-29b-3p	85.9755	NM_001317112
MOB1A	hsa-miR-29c-3p	85.9755	NM_001317112
MOB1A	hsa-miR-372-5p	85.916	NM_001317112
MOB1A	hsa-miR-5197-3p	85.8963	NM_001317112
MOB1A	hsa-miR-1250-3p	85.0116	NM_018221
MOB1A	hsa-miR-12123	84.689	NM_001317112
MOB1A	hsa-miR-6513-5p	84.6348	NM_018221
MOB1A	hsa-miR-3121-3p	84.5914	NM_001317112
MOB1A	hsa-miR-6507-5p	84.538	NM_018221
MOB1A	hsa-miR-140-5p	84.2292	NM_001317112
MOB1A	hsa-miR-548c-3p	84.1049	NM_001317112
MOB1A	hsa-miR-498-3p	84.0432	NM_001317112
MOB1A	hsa-miR-6834-3p	83.9029	NM_018221
MOB1A	hsa-miR-1299	83.0679	NM_018221
MOB1A	hsa-miR-580-3p	82.8384	NM_001317112
MOB1A	hsa-miR-4263	82.7772	NM_001317112
MOB1A	hsa-miR-3942-5p	82.664	NM_018221
MOB1A	hsa-miR-875-3p	82.4632	NM_018221
MOB1A	hsa-miR-6857-3p	81.9508	NM_018221
MOB1A	hsa-miR-5585-5p	81.7887	NM_001317112
MOB1A	hsa-miR-520b-5p	81.5868	NM_018221
MOB1A	hsa-miR-519a-2-5p	81.5868	NM_018221
MOB1A	hsa-miR-4694-3p	80.8799	NM_018221
MOB1A	hsa-miR-1252-3p	80.8303	NM_018221
MOB1A	hsa-miR-6718-5p	80.1358	NM_001317112

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Motifs and transcription factors (TFs) regulating MOB1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MOB1A	metacluster_151.2	ZNF23 (directAnnotation).
MOB1A	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MOB1A	hdpi__ETV4	ETV4 (directAnnotation).
MOB1A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MOB1A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MOB1A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MOB1A	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
MOB1A	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
MOB1A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
MOB1A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MOB1A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MOB1A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MOB1A	metacluster_175.1	ZNF283 (directAnnotation).
MOB1A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MOB1A	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MOB1A	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
MOB1A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
MOB1A	transfac_pro__M07310	SP5 (directAnnotation).
MOB1A	transfac_pro__M04893	TAF1 (directAnnotation).
MOB1A	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
MOB1A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MOB1A	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
MOB1A	metacluster_141.2	E2F2; E2F3 (directAnnotation).
MOB1A	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
MOB1A	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
MOB1A	metacluster_90.10	ZNF135 (directAnnotation).
MOB1A	taipale_tf_pairs__HOXB2_RFX5_SYMATTANNNNNNRGCAACN_CAP_repr	HOXB2; RFX5 (directAnnotation).
MOB1A	transfac_pro__M06847	SALL3 (inferredBy_Orthology).
MOB1A	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP	ELK1; POU2F1 (directAnnotation).
MOB1A	hdpi__FEZF2	FEZF2 (directAnnotation).
MOB1A	hdpi__HTATIP2	HTATIP2 (directAnnotation).
MOB1A	hdpi__HIP2	UBE2K (directAnnotation).
MOB1A	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
MOB1A	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
MOB1A	transfac_pro__M01783	SP2 (directAnnotation).
MOB1A	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
MOB1A	transfac_pro__M06488	ZNF595 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."