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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MMS22L

Summary for MMS22L

Gene information	Gene symbol	MMS22L
	Ensembl ID	ENSG00000146263
	Entrez ID	253714
	Gene name	MMS22 like, DNA repair protein
	Synonyms	C6orf167\|dJ39B17.2
	Gene type	protein_coding
	UniProtAcc	Q6ZRQ5

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Dataset with differentially expressed gene: MMS22L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.399302	7.27e-33
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.3655	0.00e+00

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Expression of MMS22L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MMS22L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MMS22L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MMS22L	hsa-miR-8485	99.9026	NM_198468
MMS22L	hsa-miR-3529-3p	98.0201	NM_198468
MMS22L	hsa-miR-98-3p	97.1032	NM_198468
MMS22L	hsa-let-7b-3p	96.699	NM_198468
MMS22L	hsa-let-7f-1-3p	96.699	NM_198468
MMS22L	hsa-let-7a-3p	96.699	NM_198468
MMS22L	hsa-let-7f-2-3p	96.4825	NM_198468
MMS22L	hsa-miR-1185-1-3p	96.4141	NM_198468
MMS22L	hsa-miR-1185-2-3p	96.4141	NM_198468
MMS22L	hsa-miR-4795-3p	96.3274	NM_198468
MMS22L	hsa-miR-4789-5p	95.3924	NM_198468
MMS22L	hsa-miR-651-3p	94.512	NM_198468
MMS22L	hsa-miR-4719	93.6781	NM_198468
MMS22L	hsa-miR-4422	93.4061	NM_198468
MMS22L	hsa-miR-32-3p	92.455	NM_198468
MMS22L	hsa-miR-190a-3p	91.9967	NM_198468
MMS22L	hsa-miR-4500	91.2543	NM_198468
MMS22L	hsa-miR-660-3p	90.6566	NM_198468
MMS22L	hsa-miR-4666a-3p	90.6313	NM_198468
MMS22L	hsa-miR-590-3p	88.8261	NM_198468
MMS22L	hsa-miR-5011-5p	88.6491	NM_198468
MMS22L	hsa-miR-600	86.8223	NM_198468
MMS22L	hsa-miR-3978	86.8086	NM_198468
MMS22L	hsa-miR-5683	86.0393	NM_198468
MMS22L	hsa-miR-4650-3p	85.6248	NM_198468
MMS22L	hsa-miR-4524b-3p	85.5331	NM_198468
MMS22L	hsa-miR-3941	85.5313	NM_198468
MMS22L	hsa-miR-300	85.4471	NM_198468
MMS22L	hsa-miR-381-3p	85.4471	NM_198468
MMS22L	hsa-miR-153-5p	85.3011	NM_198468
MMS22L	hsa-miR-12136	84.3887	NM_198468
MMS22L	hsa-let-7f-5p	84.0463	NM_198468
MMS22L	hsa-miR-4659b-3p	82.8578	NM_198468
MMS22L	hsa-miR-4659a-3p	82.8578	NM_198468
MMS22L	hsa-miR-410-3p	82.8444	NM_198468
MMS22L	hsa-miR-548c-3p	82.8144	NM_198468
MMS22L	hsa-let-7d-5p	82.3153	NM_198468
MMS22L	hsa-miR-4458	82.3153	NM_198468
MMS22L	hsa-let-7c-5p	81.579	NM_198468
MMS22L	hsa-let-7a-5p	81.579	NM_198468
MMS22L	hsa-miR-98-5p	81.579	NM_198468
MMS22L	hsa-let-7i-5p	81.579	NM_198468
MMS22L	hsa-let-7e-5p	81.579	NM_198468
MMS22L	hsa-let-7b-5p	81.579	NM_198468
MMS22L	hsa-let-7g-5p	81.579	NM_198468
MMS22L	hsa-miR-126-5p	81.312	NM_198468
MMS22L	hsa-miR-4328	81.0777	NM_198468
MMS22L	hsa-miR-4672	80.7739	NM_198468
MMS22L	hsa-miR-4720-3p	80.2345	NM_198468
MMS22L	hsa-miR-944	80.1474	NM_198468

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Motifs and transcription factors (TFs) regulating MMS22L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MMS22L	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MMS22L	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
MMS22L	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MMS22L	jaspar__MA1122.1	TFDP1 (directAnnotation).
MMS22L	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MMS22L	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MMS22L	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."