Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MMP9

Summary for MMP9

Gene information	Gene symbol	MMP9
	Ensembl ID	ENSG00000100985
	Entrez ID	4318
	Gene name	matrix metallopeptidase 9
	Synonyms	CLG4B
	Gene type	protein_coding
	UniProtAcc	P14780

Top

Dataset with differentially expressed gene: MMP9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	1.69458	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-2.31489	9.39e-23
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-2.55441	0.00e+00

Top

Expression of MMP9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MMP9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MMP9	Regulation by the Disease Microenvironment

Page: 1

Top

MicroRNAs (miRNA) regulating MMP9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Top

Motifs and transcription factors (TFs) regulating MMP9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MMP9	transfac_pro__M05896	ZNF713 (directAnnotation).
MMP9	transfac_pro__M06604	ZNF524 (directAnnotation).
MMP9	tfdimers__MD00129	CRX; NKX3-2 (directAnnotation).
MMP9	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
MMP9	hdpi__FLI1	FLI1 (directAnnotation).
MMP9	transfac_pro__M04886	ETS1 (directAnnotation).
MMP9	taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr	ELK1; PAX5 (directAnnotation).
MMP9	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
MMP9	swissregulon__hs__SPI1	SPI1 (directAnnotation).
MMP9	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
MMP9	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MMP9	transfac_pro__M01239	RELA (directAnnotation).
MMP9	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
MMP9	transfac_pro__M04706	RELA (directAnnotation).
MMP9	transfac_pro__M06484	ZNF683 (directAnnotation).
MMP9	metacluster_167.7	IRF8 (inferredBy_Orthology).
MMP9	tfdimers__MD00409	ETS1; YY2 (directAnnotation).
MMP9	metacluster_22.13	MAFK (inferredBy_Orthology).
MMP9	transfac_pro__M05612	ZNF189 (directAnnotation).
MMP9	metacluster_155.35	FIZ1; ZNF322 (directAnnotation). ZNF322 (inferredBy_Orthology).
MMP9	metacluster_22.20	MAFG (directAnnotation).
MMP9	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
MMP9	metacluster_22.17	NFE2 (directAnnotation).
MMP9	metacluster_22.25	NFE2L2 (directAnnotation).
MMP9	transfac_pro__M06334	ZNF782 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MMP9	"(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE"	DB07246	small molecule
MMP9	"(3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID"	DB07285	small molecule
MMP9	"2-Amino-N,3,3-Trimethylbutanamide"	DB01949	small molecule
MMP9	"2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid"	DB03683	small molecule
MMP9	"5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE"	DB07117	small molecule
MMP9	"AE-941"	DB05387	small molecule
MMP9	"Captopril"	DB01197	small molecule
MMP9	"Endostatin"	DB06423	biotech
MMP9	"Glutathione"	DB00143	small molecule
MMP9	"Marimastat"	DB00786	small molecule
MMP9	"Minocycline"	DB01017	small molecule
MMP9	"Oleandrin"	DB12843	small molecule
MMP9	"PG-530742"	DB05495	small molecule
MMP9	"Zinc acetate"	DB14487	small molecule
MMP9	"Zinc chloride"	DB14533	small molecule
MMP9	"Zinc sulfate, unspecified form"	DB14548	small molecule
MMP9	"Zinc"	DB01593	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."