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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MMP13

Summary for MMP13

Gene information	Gene symbol	MMP13
	Ensembl ID	ENSG00000137745
	Entrez ID	4322
	Gene name	matrix metallopeptidase 13
	Synonyms	CLG3
	Gene type	protein_coding
	UniProtAcc	P45452

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Dataset with differentially expressed gene: MMP13

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-6.33597	1.18e-02

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Expression of MMP13 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MMP13

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MMP13

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MMP13	hsa-miR-5692a	95.6819	NM_002427
MMP13	hsa-miR-4317	94.9536	NM_002427
MMP13	hsa-miR-6074	94.2931	NM_002427
MMP13	hsa-miR-501-5p	92.777	NM_002427
MMP13	hsa-miR-3678-3p	90.5006	NM_002427
MMP13	hsa-miR-6720-5p	89.7926	NM_002427
MMP13	hsa-miR-6512-3p	89.7926	NM_002427
MMP13	hsa-miR-1277-5p	89.6835	NM_002427
MMP13	hsa-miR-3657	89.6452	NM_002427
MMP13	hsa-miR-1267	88.6804	NM_002427
MMP13	hsa-miR-130a-5p	88.1008	NM_002427
MMP13	hsa-miR-891b	86.4679	NM_002427
MMP13	hsa-miR-6882-5p	85.1582	NM_002427
MMP13	hsa-miR-548ah-5p	84.669	NM_002427
MMP13	hsa-miR-3609	84.669	NM_002427
MMP13	hsa-miR-152-3p	84.6571	NM_002427
MMP13	hsa-miR-148b-3p	84.6571	NM_002427
MMP13	hsa-miR-148a-3p	84.6571	NM_002427
MMP13	hsa-miR-664a-3p	82.5939	NM_002427

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Motifs and transcription factors (TFs) regulating MMP13

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MMP13	"2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide"	DB02049	small molecule
MMP13	"3-Methylpyridine"	DB01996	small molecule
MMP13	"4-methoxybenzenesulfinate"	DB03033	small molecule
MMP13	"4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACI	DB07827	small molecule
MMP13	"5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE"	DB08388	small molecule
MMP13	"BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE"	DB08561	small molecule
MMP13	"CTS-1027"	DB08490	small molecule
MMP13	"Endostatin"	DB06423	biotech
MMP13	"Hydroxyaminovaline"	DB02697	small molecule
MMP13	"Marimastat"	DB00786	small molecule
MMP13	"PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE)"	DB04759	small molecule
MMP13	"PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE)"	DB04760	small molecule
MMP13	"PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE]"	DB04761	small molecule
MMP13	"TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-	DB07013	small molecule
MMP13	"WAY-151693"	DB02071	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."