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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MLXIP

Summary for MLXIP

Gene information	Gene symbol	MLXIP
	Ensembl ID	ENSG00000281178
	Entrez ID	22877
	Gene name	MLX interacting protein
	Synonyms	bHLHe36\|KIAA0867\|MIR\|MONDOA
	Gene type	protein_coding
	UniProtAcc	Q9HAP2

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Dataset with differentially expressed gene: MLXIP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.640902	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.304737	6.81e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.670012	3.93e-02
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.291559	5.85e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.368005	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.353049	8.89e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.327461	0.00e+00

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Expression of MLXIP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MLXIP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MLXIP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MLXIP	hsa-miR-8485	98.2308	NM_014938
MLXIP	hsa-miR-211-5p	98.1647	NM_014938
MLXIP	hsa-miR-204-5p	98.1647	NM_014938
MLXIP	hsa-miR-4755-5p	97.3146	NM_014938
MLXIP	hsa-miR-5006-3p	97.3146	NM_014938
MLXIP	hsa-miR-6721-5p	96.6808	NM_014938
MLXIP	hsa-miR-4763-5p	96.5789	NM_014938
MLXIP	hsa-miR-1205	95.5989	NM_014938
MLXIP	hsa-miR-10394-5p	95.5989	NM_014938
MLXIP	hsa-miR-3619-5p	95.2745	NM_014938
MLXIP	hsa-miR-6832-3p	95.2417	NM_014938
MLXIP	hsa-miR-30c-5p	94.8768	NM_014938
MLXIP	hsa-miR-30a-5p	94.8768	NM_014938
MLXIP	hsa-miR-30b-5p	94.8768	NM_014938
MLXIP	hsa-miR-30e-5p	94.8768	NM_014938
MLXIP	hsa-miR-30d-5p	94.8768	NM_014938
MLXIP	hsa-miR-607	93.6456	NM_014938
MLXIP	hsa-miR-5701	93.4541	NM_014938
MLXIP	hsa-miR-214-3p	93.0396	NM_014938
MLXIP	hsa-miR-761	93.0104	NM_014938
MLXIP	hsa-miR-2467-3p	91.1339	NM_014938
MLXIP	hsa-miR-6134	91.0358	NM_014938
MLXIP	hsa-miR-3613-3p	90.412	NM_014938
MLXIP	hsa-miR-505-3p	89.7665	NM_014938
MLXIP	hsa-miR-4262	87.599	NM_014938
MLXIP	hsa-miR-922	87.3501	NM_014938
MLXIP	hsa-miR-1207-5p	86.6483	NM_014938
MLXIP	hsa-miR-623	86.5076	NM_014938
MLXIP	hsa-miR-519d-5p	86.454	NM_014938
MLXIP	hsa-miR-4722-3p	85.7813	NM_014938
MLXIP	hsa-miR-6727-3p	85.7813	NM_014938
MLXIP	hsa-miR-29b-3p	85.6822	NM_014938
MLXIP	hsa-miR-29a-3p	85.6822	NM_014938
MLXIP	hsa-miR-29c-3p	85.6822	NM_014938
MLXIP	hsa-miR-3663-3p	85.5711	NM_014938
MLXIP	hsa-miR-519e-5p	85.2122	NM_014938
MLXIP	hsa-miR-515-5p	85.2122	NM_014938
MLXIP	hsa-miR-4763-3p	85.2107	NM_014938
MLXIP	hsa-miR-4633-3p	84.9831	NM_014938
MLXIP	hsa-miR-6500-5p	84.9831	NM_014938
MLXIP	hsa-miR-5093	84.9117	NM_014938
MLXIP	hsa-miR-181b-5p	84.6234	NM_014938
MLXIP	hsa-miR-181a-5p	84.6234	NM_014938
MLXIP	hsa-miR-181c-5p	84.6234	NM_014938
MLXIP	hsa-miR-181d-5p	84.6234	NM_014938
MLXIP	hsa-miR-142-3p	84.3514	NM_014938
MLXIP	hsa-miR-4456	84.1625	NM_014938
MLXIP	hsa-miR-6132	83.5991	NM_014938
MLXIP	hsa-miR-6836-5p	83.5991	NM_014938
MLXIP	hsa-miR-499b-5p	83.5806	NM_014938

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Motifs and transcription factors (TFs) regulating MLXIP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MLXIP	metacluster_7.13	ZFX (directAnnotation).
MLXIP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MLXIP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MLXIP	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
MLXIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MLXIP	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MLXIP	metacluster_141.2	E2F2; E2F3 (directAnnotation).
MLXIP	hdpi__TP73	TP73 (directAnnotation).
MLXIP	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
MLXIP	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
MLXIP	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
MLXIP	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."