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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MLLT6

Summary for MLLT6

Gene information	Gene symbol	MLLT6
	Ensembl ID	ENSG00000275851
	Entrez ID	4302
	Gene name	MLLT6, PHD finger containing
	Synonyms	AF17\|FLJ23480
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MLLT6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.27325	1.68e-04

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Expression of MLLT6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MLLT6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MLLT6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MLLT6	hsa-miR-8485	99.9935	NM_005937
MLLT6	hsa-miR-4728-5p	96.6925	NM_005937
MLLT6	hsa-miR-130b-3p	95.8286	NM_005937
MLLT6	hsa-miR-130a-3p	95.8286	NM_005937
MLLT6	hsa-miR-6785-5p	95.6614	NM_005937
MLLT6	hsa-miR-454-3p	95.6295	NM_005937
MLLT6	hsa-miR-149-3p	94.9676	NM_005937
MLLT6	hsa-miR-6883-5p	94.5506	NM_005937
MLLT6	hsa-miR-301a-3p	93.7963	NM_005937
MLLT6	hsa-miR-4295	93.7963	NM_005937
MLLT6	hsa-miR-3666	93.7963	NM_005937
MLLT6	hsa-miR-301b-3p	93.7963	NM_005937
MLLT6	hsa-miR-520d-5p	93.4708	NM_005937
MLLT6	hsa-miR-524-5p	93.4708	NM_005937
MLLT6	hsa-miR-5088-3p	92.7774	NM_005937
MLLT6	hsa-miR-1587	92.2981	NM_005937
MLLT6	hsa-miR-92a-2-5p	91.8627	NM_005937
MLLT6	hsa-miR-3667-3p	90.7087	NM_005937
MLLT6	hsa-miR-4656	89.9599	NM_005937
MLLT6	hsa-miR-4700-5p	89.8979	NM_005937
MLLT6	hsa-miR-361-3p	89.2552	NM_005937
MLLT6	hsa-miR-12125	88.665	NM_005937
MLLT6	hsa-miR-6134	88.2347	NM_005937
MLLT6	hsa-miR-8089	87.8092	NM_005937
MLLT6	hsa-miR-6886-3p	87.7279	NM_005937
MLLT6	hsa-miR-92a-1-5p	87.4288	NM_005937
MLLT6	hsa-miR-4667-5p	87.313	NM_005937
MLLT6	hsa-miR-3620-5p	87.0252	NM_005937
MLLT6	hsa-miR-450b-5p	86.352	NM_005937
MLLT6	hsa-miR-152-3p	86.2958	NM_005937
MLLT6	hsa-miR-148b-3p	86.2958	NM_005937
MLLT6	hsa-miR-148a-3p	86.2958	NM_005937
MLLT6	hsa-miR-98-3p	86.1304	NM_005937
MLLT6	hsa-let-7a-3p	86.1304	NM_005937
MLLT6	hsa-let-7f-1-3p	86.1304	NM_005937
MLLT6	hsa-let-7b-3p	86.1304	NM_005937
MLLT6	hsa-miR-4671-3p	86.0271	NM_005937
MLLT6	hsa-miR-432-5p	86.0184	NM_005937
MLLT6	hsa-miR-887-5p	85.7371	NM_005937
MLLT6	hsa-miR-512-3p	85.0441	NM_005937
MLLT6	hsa-miR-19a-3p	84.6186	NM_005937
MLLT6	hsa-miR-19b-3p	84.6186	NM_005937
MLLT6	hsa-miR-4487	84.5512	NM_005937
MLLT6	hsa-miR-6826-3p	83.9887	NM_005937
MLLT6	hsa-miR-342-3p	83.8472	NM_005937
MLLT6	hsa-miR-6887-5p	83.4412	NM_005937
MLLT6	hsa-miR-18a-3p	83.3014	NM_005937
MLLT6	hsa-miR-665	82.5998	NM_005937
MLLT6	hsa-miR-1207-5p	81.9083	NM_005937
MLLT6	hsa-miR-6887-3p	81.8019	NM_005937

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Motifs and transcription factors (TFs) regulating MLLT6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MLLT6	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MLLT6	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MLLT6	transfac_pro__M05829	ZNF627 (directAnnotation).
MLLT6	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
MLLT6	metacluster_134.5	ZNF184 (directAnnotation).
MLLT6	taipale_tf_pairs__GCM1_MAX_NNCACGTGNNNGCGGGYN_CAP_repr	GCM1; MAX (directAnnotation).
MLLT6	transfac_pro__M06042	ZNF208 (directAnnotation).
MLLT6	tfdimers__MD00463	CHURC1; DBP (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."