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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MLF1

Summary for MLF1

Gene information	Gene symbol	MLF1
	Ensembl ID	ENSG00000178053
	Entrez ID	4291
	Gene name	myeloid leukemia factor 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MLF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.306456	5.59e-20
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.490178	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.376859	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.263203	2.85e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.399941	0.00e+00

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Expression of MLF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MLF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MLF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MLF1	hsa-miR-4299	94.0387	NM_022443
MLF1	hsa-miR-4766-3p	94.0204	NM_022443
MLF1	hsa-miR-320c	93.4572	NM_022443
MLF1	hsa-miR-320d	93.4572	NM_022443
MLF1	hsa-miR-4429	93.4572	NM_022443
MLF1	hsa-miR-320b	93.4572	NM_022443
MLF1	hsa-miR-320a-3p	93.4572	NM_022443
MLF1	hsa-miR-302c-5p	90.7239	NM_022443
MLF1	hsa-miR-4311	89.7929	NM_001130156
MLF1	hsa-miR-10397-5p	89.6072	NM_022443
MLF1	hsa-miR-380-3p	89.2815	NM_022443
MLF1	hsa-miR-590-3p	87.9796	NM_022443
MLF1	hsa-miR-767-5p	87.727	NM_001130156
MLF1	hsa-miR-4307	87.3868	NM_022443
MLF1	hsa-miR-4528	86.7656	NM_022443
MLF1	hsa-miR-7-1-3p	86.3846	NM_022443
MLF1	hsa-miR-7-2-3p	86.3846	NM_022443
MLF1	hsa-miR-196a-1-3p	84.8647	NM_022443
MLF1	hsa-miR-656-3p	84.8448	NM_022443
MLF1	hsa-miR-5583-5p	84.3779	NM_022443
MLF1	hsa-miR-3129-3p	84.3779	NM_022443
MLF1	hsa-miR-509-3p	84.0277	NM_001130156
MLF1	hsa-miR-3159	83.9824	NM_022443
MLF1	hsa-miR-1303	83.7451	NM_022443
MLF1	hsa-miR-3163	83.465	NM_022443
MLF1	hsa-miR-6843-3p	82.8692	NM_001130156
MLF1	hsa-miR-6848-3p	82.8692	NM_001130156
MLF1	hsa-miR-3923	82.733	NM_022443
MLF1	hsa-miR-3143	82.2308	NM_022443
MLF1	hsa-miR-6848-5p	81.7577	NM_022443
MLF1	hsa-miR-6846-5p	81.7577	NM_022443
MLF1	hsa-miR-3942-3p	80.4901	NM_022443

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Motifs and transcription factors (TFs) regulating MLF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MLF1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MLF1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MLF1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
MLF1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
MLF1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
MLF1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MLF1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
MLF1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
MLF1	jaspar__MA1483.2	ELF2 (directAnnotation).
MLF1	cisbp__M00808	MYPOP (inferredBy_Orthology).
MLF1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MLF1	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
MLF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MLF1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
MLF1	jaspar__MA1957.1	ELK1 (directAnnotation).
MLF1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MLF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MLF1	transfac_pro__M07397	ZNF148 (directAnnotation).
MLF1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
MLF1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
MLF1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
MLF1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MLF1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MLF1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MLF1	transfac_pro__M01175	ZBTB7B (directAnnotation).
MLF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MLF1	tfdimers__MD00151	CHURC1 (directAnnotation).
MLF1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MLF1	transfac_pro__M01303	SP1 (directAnnotation).
MLF1	transfac_pro__M01714	KLF15 (directAnnotation).
MLF1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
MLF1	transfac_pro__M12604	ZNF444 (directAnnotation).
MLF1	metacluster_3.14	WT1; WT1 (directAnnotation).
MLF1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
MLF1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MLF1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
MLF1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
MLF1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
MLF1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MLF1	transfac_pro__M07436	WT1 (directAnnotation).
MLF1	transfac_pro__M02281	SP1 (directAnnotation).
MLF1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MLF1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
MLF1	transfac_public__M00491	PATZ1 (directAnnotation).
MLF1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
MLF1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MLF1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
MLF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MLF1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
MLF1	cisbp__M00249	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."