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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MLEC

Summary for MLEC

Gene information	Gene symbol	MLEC
	Ensembl ID	ENSG00000110917
	Entrez ID	9761
	Gene name	malectin
	Synonyms	KIAA0152
	Gene type	protein_coding
	UniProtAcc	Q14165

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Dataset with differentially expressed gene: MLEC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.2852	3.68e-10
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.455802	2.20e-37
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.261804	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.39789	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.312256	3.13e-11
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.387536	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.288801	1.65e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.598058	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.346281	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.614806	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.338204	1.66e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.30006	1.99e-09
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.365924	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.332618	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.355704	8.83e-25
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.465815	0.00e+00

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Expression of MLEC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MLEC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MLEC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MLEC	hsa-miR-4533	98.1638	NM_001303628
MLEC	hsa-miR-3667-3p	97.0137	NM_001303627
MLEC	hsa-miR-6840-3p	96.2706	NM_001303627
MLEC	hsa-miR-6868-3p	96.0973	NM_001303627
MLEC	hsa-miR-3202	95.8713	NM_001303628
MLEC	hsa-miR-6758-5p	95.585	NM_001303628
MLEC	hsa-miR-6856-5p	95.585	NM_001303628
MLEC	hsa-miR-24-3p	94.9895	NM_001303628
MLEC	hsa-miR-4308	94.8776	NM_001303627
MLEC	hsa-miR-373-5p	94.0352	NM_001303627
MLEC	hsa-miR-371b-5p	94.0352	NM_001303627
MLEC	hsa-miR-616-5p	94.0352	NM_001303627
MLEC	hsa-miR-4698	93.7069	NM_001303627
MLEC	hsa-miR-6791-5p	93.6631	NM_001303627
MLEC	hsa-miR-4292	93.6631	NM_001303627
MLEC	hsa-miR-9851-5p	93.4801	NM_001303628
MLEC	hsa-miR-5002-3p	92.9385	NM_001303627
MLEC	hsa-miR-101-3p	92.6158	NM_001303627
MLEC	hsa-miR-5688	92.3313	NM_001303628
MLEC	hsa-miR-370-3p	92.1366	NM_001303627
MLEC	hsa-miR-495-3p	91.9117	NM_001303628
MLEC	hsa-miR-4661-3p	91.4912	NM_001303627
MLEC	hsa-miR-6764-5p	91.4796	NM_001303627
MLEC	hsa-miR-5580-5p	91.3643	NM_001303628
MLEC	hsa-miR-4261	91.2642	NM_001303627
MLEC	hsa-miR-6893-3p	91.1541	NM_001303627
MLEC	hsa-miR-7113-5p	90.5878	NM_001303627
MLEC	hsa-miR-6806-3p	90.2849	NM_001303628
MLEC	hsa-miR-3928-5p	90.2849	NM_001303628
MLEC	hsa-miR-6734-3p	90.2415	NM_001303627
MLEC	hsa-miR-1915-3p	89.6975	NM_001303627
MLEC	hsa-miR-6134	89.6789	NM_001303628
MLEC	hsa-miR-6752-3p	89.5903	NM_001303627
MLEC	hsa-miR-4269	89.2068	NM_001303627
MLEC	hsa-miR-6715b-5p	89.2068	NM_001303627
MLEC	hsa-miR-1178-5p	89.1752	NM_001303627
MLEC	hsa-miR-6893-5p	89.0347	NM_001303628
MLEC	hsa-miR-6808-5p	89.0347	NM_001303628
MLEC	hsa-miR-940	89.0315	NM_001303628
MLEC	hsa-miR-4430	88.8588	NM_001303627
MLEC	hsa-miR-3652	88.8588	NM_001303627
MLEC	hsa-miR-4289	88.8175	NM_001303628
MLEC	hsa-miR-147b-5p	88.4792	NM_001303627
MLEC	hsa-miR-4713-5p	88.4365	NM_001303627
MLEC	hsa-miR-10527-5p	88.2449	NM_001303627
MLEC	hsa-miR-4722-3p	87.6068	NM_001303627
MLEC	hsa-miR-4704-3p	87.4714	NM_001303628
MLEC	hsa-miR-6727-3p	87.3682	NM_001303627
MLEC	hsa-miR-4441	86.7195	NM_001303628
MLEC	hsa-miR-874-5p	86.5652	NM_001303627

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Motifs and transcription factors (TFs) regulating MLEC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MLEC	metacluster_7.13	ZFX (directAnnotation).
MLEC	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MLEC	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MLEC	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MLEC	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MLEC	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MLEC	transfac_pro__M06071	ZNF814 (directAnnotation).
MLEC	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
MLEC	transfac_pro__M04826	EP300 (directAnnotation).
MLEC	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MLEC	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
MLEC	transfac_pro__M05481	ZNF202 (directAnnotation).
MLEC	transfac_pro__M05298	OVOL3 (directAnnotation).
MLEC	metacluster_33.5	MTF1 (inferredBy_Orthology).
MLEC	jaspar__MA1493.1	HES6 (directAnnotation).
MLEC	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
MLEC	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
MLEC	hdpi__FLI1	FLI1 (directAnnotation).
MLEC	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MLEC	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MLEC	metacluster_22.13	MAFK (inferredBy_Orthology).
MLEC	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MLEC	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
MLEC	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MLEC	transfac_pro__M04844	MAX (directAnnotation).
MLEC	metacluster_10.30	MXI1 (inferredBy_Orthology).
MLEC	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
MLEC	jaspar__MA1483.2	ELF2 (directAnnotation).
MLEC	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MLEC	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MLEC	jaspar__MA1933.1	SREBF2 (directAnnotation).
MLEC	jaspar__MA1708.1	ETV7 (directAnnotation).
MLEC	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MLEC	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MLEC	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
MLEC	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
MLEC	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MLEC	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
MLEC	metacluster_182.10	ZFX (directAnnotation).
MLEC	transfac_pro__M00492	STAT1 (directAnnotation).
MLEC	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
MLEC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
MLEC	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
MLEC	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
MLEC	jaspar__MA0502.2	NFYB (directAnnotation).
MLEC	transfac_pro__M06141	ZNF708 (directAnnotation).
MLEC	transfac_pro__M05835	ZNF628 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."