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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MINK1

Summary for MINK1

Gene information	Gene symbol	MINK1
	Ensembl ID	ENSG00000141503
	Entrez ID	50488
	Gene name	misshapen like kinase 1
	Synonyms	B55\|MAP4K6\|MINK\|YSK2\|ZC3
	Gene type	protein_coding
	UniProtAcc	Q8N4C8

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Dataset with differentially expressed gene: MINK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.376557	1.10e-07

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Expression of MINK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MINK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MINK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MINK1	hsa-miR-511-5p	95.4439	NM_001024937
MINK1	hsa-miR-6887-5p	95.0826	NM_001321236
MINK1	hsa-miR-4717-5p	94.2386	NM_001024937
MINK1	hsa-miR-6795-5p	94.1573	NM_001321236
MINK1	hsa-miR-219a-2-3p	90.041	NM_001321236
MINK1	hsa-miR-4728-5p	89.4881	NM_001321236
MINK1	hsa-miR-6783-3p	89.4557	NM_001024937
MINK1	hsa-miR-4254	88.5793	NM_001024937
MINK1	hsa-miR-1343-3p	86.9493	NM_001024937
MINK1	hsa-miR-20a-5p	86.3784	NM_001321236
MINK1	hsa-miR-106b-5p	86.3784	NM_001321236
MINK1	hsa-miR-519d-3p	86.1476	NM_001321236
MINK1	hsa-miR-526b-3p	86.1476	NM_001321236
MINK1	hsa-miR-93-5p	86.1476	NM_001321236
MINK1	hsa-miR-20b-5p	86.1476	NM_001321236
MINK1	hsa-miR-17-5p	86.1476	NM_001321236
MINK1	hsa-miR-106a-5p	86.1476	NM_001321236
MINK1	hsa-miR-6783-5p	86.1134	NM_001321236
MINK1	hsa-miR-6752-3p	85.7897	NM_001024937
MINK1	hsa-miR-4308	85.405	NM_001024937
MINK1	hsa-miR-6785-5p	85.2875	NM_001321236
MINK1	hsa-miR-149-3p	85.2875	NM_001321236
MINK1	hsa-miR-6883-5p	85.2875	NM_001321236
MINK1	hsa-miR-6859-3p	84.5715	NM_001321236
MINK1	hsa-miR-5683	84.1032	NM_001321236
MINK1	hsa-miR-6715b-3p	83.8402	NM_001321236
MINK1	hsa-miR-670-5p	83.2271	NM_001024937
MINK1	hsa-miR-6715a-3p	82.9055	NM_001321236
MINK1	hsa-miR-6780b-5p	82.1047	NM_001321236
MINK1	hsa-miR-4725-3p	82.1047	NM_001321236
MINK1	hsa-miR-7111-5p	81.9644	NM_001321236
MINK1	hsa-miR-4723-5p	81.9644	NM_001321236
MINK1	hsa-miR-6870-5p	81.9644	NM_001321236
MINK1	hsa-miR-5698	81.9644	NM_001321236
MINK1	hsa-miR-6830-3p	81.7653	NM_001024937
MINK1	hsa-miR-548e-5p	81.3252	NM_001321236
MINK1	hsa-miR-4262	80.7539	NM_001024937

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Motifs and transcription factors (TFs) regulating MINK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MINK1	jaspar__MA1633.2	BACH1 (directAnnotation).
MINK1	metacluster_155.29	ZNF2 (directAnnotation). ZNF2 (inferredBy_Orthology).
MINK1	tfdimers__MD00097	GABPA; PAX4 (directAnnotation).
MINK1	transfac_pro__M06353	ZNF782 (directAnnotation).
MINK1	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
MINK1	transfac_pro__M06158	ZNF157 (directAnnotation).
MINK1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MINK1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."