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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MINDY2

Summary for MINDY2

Gene information	Gene symbol	MINDY2
	Ensembl ID	ENSG00000128923
	Entrez ID	54629
	Gene name	MINDY lysine 48 deubiquitinase 2
	Synonyms	FAM63B\|KIAA1164
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MINDY2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.269917	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.313963	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.410479	4.20e-45

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Expression of MINDY2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MINDY2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MINDY2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MINDY2	hsa-miR-205-3p	99.9169	NM_001040453
MINDY2	hsa-miR-7-1-3p	99.8301	NM_001040453
MINDY2	hsa-miR-7-2-3p	99.8301	NM_001040453
MINDY2	hsa-miR-4282	99.8251	NM_001040453
MINDY2	hsa-miR-7856-5p	99.7499	NM_001040453
MINDY2	hsa-miR-218-5p	99.5922	NM_001040453
MINDY2	hsa-miR-5688	99.501	NM_001040453
MINDY2	hsa-miR-559	99.4572	NM_001040453
MINDY2	hsa-miR-548a-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548bb-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548am-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ad-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ay-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548as-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ae-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548b-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548i	99.4213	NM_001040453
MINDY2	hsa-miR-548d-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548w	99.4213	NM_001040453
MINDY2	hsa-miR-548h-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548j-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ak	99.4213	NM_001040453
MINDY2	hsa-miR-548c-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ap-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ar-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548o-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548au-5p	99.4213	NM_001040453
MINDY2	hsa-miR-548ab	99.4213	NM_001040453
MINDY2	hsa-miR-548y	99.4213	NM_001040453
MINDY2	hsa-miR-548at-5p	99.1083	NM_001040453
MINDY2	hsa-miR-29a-5p	99.0806	NM_001040453
MINDY2	hsa-miR-495-3p	99.0053	NM_001040453
MINDY2	hsa-miR-548aq-5p	99.0002	NM_001040453
MINDY2	hsa-miR-9983-3p	98.8598	NM_001040453
MINDY2	hsa-miR-670-3p	98.8349	NM_001040453
MINDY2	hsa-miR-129-5p	98.7387	NM_001040453
MINDY2	hsa-miR-514b-5p	98.3565	NM_001040453
MINDY2	hsa-miR-513c-5p	98.3565	NM_001040453
MINDY2	hsa-miR-5009-3p	97.9293	NM_001040453
MINDY2	hsa-miR-4637	97.6893	NM_001040453
MINDY2	hsa-miR-3973	97.5782	NM_001040453
MINDY2	hsa-miR-561-5p	97.1663	NM_001040453
MINDY2	hsa-miR-4799-5p	96.723	NM_001040453
MINDY2	hsa-miR-320d	96.7009	NM_001040453
MINDY2	hsa-miR-320c	96.7009	NM_001040453
MINDY2	hsa-miR-4429	96.7009	NM_001040453
MINDY2	hsa-miR-320b	96.7009	NM_001040453
MINDY2	hsa-miR-320a-3p	96.7009	NM_001040453
MINDY2	hsa-miR-154-5p	96.6558	NM_001040453
MINDY2	hsa-miR-6508-5p	96.5362	NM_001040453

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Motifs and transcription factors (TFs) regulating MINDY2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."