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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MIF4GD

Summary for MIF4GD

Gene information	Gene symbol	MIF4GD
	Ensembl ID	ENSG00000125457
	Entrez ID	57409
	Gene name	MIF4G domain containing
	Synonyms	AD023\|MGC45027\|MIFD\|SLIP1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MIF4GD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.322684	1.12e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.62825	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.316162	7.92e-14

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Expression of MIF4GD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MIF4GD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MIF4GD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MIF4GD	hsa-miR-1827	96.5033	NM_001242498
MIF4GD	hsa-miR-6769b-5p	96.1922	NM_001242498
MIF4GD	hsa-miR-6769a-5p	95.111	NM_001242498
MIF4GD	hsa-miR-2115-3p	90.5863	NM_001242501
MIF4GD	hsa-let-7a-3p	88.6188	NM_001242501
MIF4GD	hsa-let-7b-3p	88.6188	NM_001242501
MIF4GD	hsa-miR-98-3p	88.6188	NM_001242501
MIF4GD	hsa-let-7f-1-3p	88.6188	NM_001242501
MIF4GD	hsa-miR-3202	87.1863	NM_001242501
MIF4GD	hsa-miR-92a-2-5p	84.3172	NM_001242501
MIF4GD	hsa-miR-766-5p	83.9862	NM_001242501
MIF4GD	hsa-miR-4698	81.2602	NM_001242498
MIF4GD	hsa-miR-6733-5p	80.2298	NM_001242501

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Motifs and transcription factors (TFs) regulating MIF4GD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MIF4GD	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
MIF4GD	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
MIF4GD	taipale_tf_pairs__TEAD4_HOXA13_GGWATGNNNRTAAA_CAP_repr	HOXA13; TEAD4 (directAnnotation).
MIF4GD	transfac_pro__M06601	ZNF501 (directAnnotation).
MIF4GD	taipale_tf_pairs__TEAD4_HOXB13_GGWATGNNNRTAAA_CAP	HOXB13; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."