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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MIDN

Summary for MIDN

Gene information	Gene symbol	MIDN
	Ensembl ID	ENSG00000167470
	Entrez ID	90007
	Gene name	midnolin
	Synonyms	Stx
	Gene type	protein_coding
	UniProtAcc	Q504T8

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Dataset with differentially expressed gene: MIDN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.408352	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.388424	4.92e-12
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.871162	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.416184	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.548714	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.333548	2.61e-12
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.305593	8.16e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.265265	6.94e-08
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	cDCs	-0.564885	9.42e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.293784	7.32e-14
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.387305	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.834219	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.17244	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.265082	1.69e-09
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.364903	6.44e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.322033	1.92e-15
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.369602	1.78e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.33968	0.00e+00

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Expression of MIDN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MIDN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MIDN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MIDN	hsa-miR-222-3p	94.779	NM_177401
MIDN	hsa-miR-221-3p	94.779	NM_177401
MIDN	hsa-miR-24-3p	93.5554	NM_177401
MIDN	hsa-miR-155-5p	92.5357	NM_177401
MIDN	hsa-miR-335-3p	87.1952	NM_177401
MIDN	hsa-miR-106b-5p	87.074	NM_177401
MIDN	hsa-miR-20a-5p	87.074	NM_177401
MIDN	hsa-miR-6747-3p	87.0423	NM_177401
MIDN	hsa-miR-20b-5p	86.5469	NM_177401
MIDN	hsa-miR-519d-3p	86.5469	NM_177401
MIDN	hsa-miR-93-5p	86.5469	NM_177401
MIDN	hsa-miR-106a-5p	86.5469	NM_177401
MIDN	hsa-miR-17-5p	86.5469	NM_177401
MIDN	hsa-miR-526b-3p	86.5469	NM_177401
MIDN	hsa-miR-3148	85.8137	NM_177401
MIDN	hsa-miR-4731-5p	83.7766	NM_177401
MIDN	hsa-miR-5692a	82.9955	NM_177401
MIDN	hsa-miR-6887-3p	81.5831	NM_177401

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Motifs and transcription factors (TFs) regulating MIDN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MIDN	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MIDN	jaspar__MA0079.5	SP1 (directAnnotation).
MIDN	transfac_pro__M07397	ZNF148 (directAnnotation).
MIDN	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MIDN	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MIDN	transfac_pro__M01714	KLF15 (directAnnotation).
MIDN	transfac_pro__M02281	SP1 (directAnnotation).
MIDN	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
MIDN	transfac_pro__M01861	ATF1 (directAnnotation).
MIDN	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
MIDN	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
MIDN	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
MIDN	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
MIDN	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
MIDN	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
MIDN	metacluster_22.18	BACH2 (inferredBy_Orthology).
MIDN	metacluster_22.37	BACH1 (directAnnotation).
MIDN	metacluster_22.34	BACH2 (directAnnotation).
MIDN	metacluster_22.20	MAFG (directAnnotation).
MIDN	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MIDN	metacluster_22.13	MAFK (inferredBy_Orthology).
MIDN	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
MIDN	metacluster_22.33	MAFK (inferredBy_Orthology).
MIDN	jaspar__MA1125.1	ZNF384 (directAnnotation).
MIDN	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
MIDN	metacluster_32.24	ZNF287 (directAnnotation).
MIDN	metacluster_22.39	NFE2L2 (directAnnotation).
MIDN	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
MIDN	tfdimers__MD00276	IRF1; STAT6 (directAnnotation).
MIDN	metacluster_22.17	NFE2 (directAnnotation).
MIDN	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
MIDN	metacluster_111.5	E4F1; E4F1 (directAnnotation).
MIDN	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
MIDN	metacluster_22.1	MAFF (inferredBy_Orthology).
MIDN	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
MIDN	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
MIDN	transfac_pro__M02896	SPI1 (inferredBy_Orthology).
MIDN	taipale_tf_pairs__HOXB13_ONECUT2_NNNRTAAAWATYGAYY_CAP	HOXB13; ONECUT2 (directAnnotation).
MIDN	transfac_pro__M01835	KLF4 (directAnnotation).
MIDN	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
MIDN	tfdimers__MD00216	ARID3A; VDR (directAnnotation).
MIDN	tfdimers__MD00320	NANOG (directAnnotation).
MIDN	tfdimers__MD00085	MYB (directAnnotation).
MIDN	metacluster_161.39	MSX1 (directAnnotation).
MIDN	kznf__ZNF382_Najafabadi2015_ChIP-seq	ZNF382 (directAnnotation).
MIDN	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
MIDN	tfdimers__MD00187	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
MIDN	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
MIDN	tfdimers__MD00090	FOS; FOXG1; FOXO1 (directAnnotation).
MIDN	swissregulon__hs__ZBTB12	ZBTB12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."