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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MICOS10

Summary for MICOS10

Gene information	Gene symbol	MICOS10
	Ensembl ID	ENSG00000173436
	Entrez ID	440574
	Gene name	mitochondrial contact site and cristae organizing system subunit 10
	Synonyms	C1orf151\|FLJ36999\|Mic10\|MINOS1\|MIO10\|RP5-1056L3.2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MICOS10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	1.16139	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.556567	0.00e+00

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Expression of MICOS10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MICOS10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MICOS10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MICOS10	hsa-miR-544b	97.6187	NM_001204083
MICOS10	hsa-miR-1200	96.4252	NM_001204083
MICOS10	hsa-miR-29b-2-5p	93.3564	NM_001204083
MICOS10	hsa-miR-6881-3p	91.4906	NM_001204083
MICOS10	hsa-miR-7977	90.9777	NM_001204083
MICOS10	hsa-miR-520a-5p	90.5347	NM_001204083
MICOS10	hsa-miR-525-5p	90.5347	NM_001204083
MICOS10	hsa-miR-4324	89.021	NM_001204083
MICOS10	hsa-miR-7156-5p	85.3356	NM_001204083
MICOS10	hsa-miR-7853-5p	85.1747	NM_001204082
MICOS10	hsa-miR-6837-5p	84.3625	NM_001204083
MICOS10	hsa-miR-4685-5p	84.3625	NM_001204083
MICOS10	hsa-miR-4668-5p	83.5796	NM_001204082
MICOS10	hsa-miR-105-5p	83.4612	NM_001204082
MICOS10	hsa-miR-378a-5p	82.6755	NM_001204083
MICOS10	hsa-miR-6810-3p	82.6475	NM_001204082
MICOS10	hsa-miR-4273	82.5317	NM_001204083
MICOS10	hsa-miR-6799-3p	81.9057	NM_001204083
MICOS10	hsa-miR-6801-3p	80.8993	NM_001204082
MICOS10	hsa-miR-3928-3p	80.2681	NM_001204083

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Motifs and transcription factors (TFs) regulating MICOS10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."