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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MGP

Summary for MGP

Gene information	Gene symbol	MGP
	Ensembl ID	ENSG00000111341
	Entrez ID	4256
	Gene name	matrix Gla protein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P08493

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Dataset with differentially expressed gene: MGP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	2.95279	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.416825	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.344788	6.86e-24
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.313286	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.993708	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.985339	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	1.00932	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	1.23094	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-1.34387	2.15e-02
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.494318	1.45e-04
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-1.26622	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.404416	2.96e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	1.01476	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.645062	0.00e+00

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Expression of MGP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MGP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MGP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MGP	hsa-miR-4770	94.4058	NM_000900
MGP	hsa-miR-143-3p	94.4058	NM_000900
MGP	hsa-miR-548ax	93.0783	NM_000900
MGP	hsa-miR-548ao-5p	93.0783	NM_000900
MGP	hsa-miR-451b	92.3978	NM_000900
MGP	hsa-miR-3123	92.1891	NM_000900
MGP	hsa-miR-6088	91.8718	NM_000900
MGP	hsa-miR-9902	90.718	NM_000900
MGP	hsa-miR-28-3p	90.1314	NM_000900
MGP	hsa-miR-504-3p	89.725	NM_000900
MGP	hsa-miR-1248	89.313	NM_000900
MGP	hsa-miR-3064-3p	89.2514	NM_000900
MGP	hsa-miR-8070	89.1007	NM_000900
MGP	hsa-miR-1303	86.489	NM_000900
MGP	hsa-miR-4705	85.9806	NM_000900
MGP	hsa-miR-6809-3p	85.5213	NM_000900
MGP	hsa-miR-6798-5p	84.2036	NM_000900
MGP	hsa-miR-627-3p	83.8178	NM_000900
MGP	hsa-miR-8066	83.4937	NM_000900
MGP	hsa-miR-410-3p	83.3522	NM_000900
MGP	hsa-miR-7702	80.8183	NM_000900

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Motifs and transcription factors (TFs) regulating MGP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MGP	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
MGP	cisbp__M02645	ETS1 (directAnnotation).
MGP	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
MGP	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
MGP	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MGP	hdpi__TFAM	TFAM (directAnnotation).
MGP	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
MGP	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MGP	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
MGP	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MGP	swissregulon__hs__ELK1	ELK1 (directAnnotation).
MGP	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
MGP	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
MGP	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
MGP	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
MGP	metacluster_168.13	ZNF287; ZNF324; ZNF324B (directAnnotation). ZNF287 (inferredBy_Orthology).
MGP	transfac_pro__M06048	ZNF208 (directAnnotation).
MGP	transfac_pro__M06723	ZNF492 (directAnnotation).
MGP	tfdimers__MD00186	NFATC3; SPI1 (directAnnotation).
MGP	tfdimers__MD00129	CRX; NKX3-2 (directAnnotation).
MGP	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
MGP	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
MGP	metacluster_22.34	BACH2 (directAnnotation).
MGP	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
MGP	metacluster_162.1	ZNF224 (directAnnotation).
MGP	metacluster_172.22	E4F1 (inferredBy_Orthology).
MGP	tfdimers__MD00212	NFATC1; NFIA; NFIC (directAnnotation).
MGP	metacluster_168.19	ZNF316 (directAnnotation).
MGP	transfac_pro__M05791	ZNF517 (directAnnotation).
MGP	transfac_pro__M06010	ZNF701 (directAnnotation).
MGP	transfac_pro__M06473	ZNF440 (directAnnotation).
MGP	flyfactorsurvey__So_Cell_FBgn0003460	SIX1 (inferredBy_Orthology).
MGP	metacluster_107.1	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
MGP	transfac_pro__M06906	ZNF585B (directAnnotation).
MGP	transfac_pro__M06622	ZNF681 (directAnnotation).
MGP	transfac_pro__M06564	ZNF578 (directAnnotation).
MGP	transfac_pro__M05982	ZFP14 (directAnnotation).
MGP	metacluster_165.6	ONECUT1; ONECUT1; ONECUT2; ONECUT2 (directAnnotation).
MGP	transfac_pro__M06104	ZNF16 (directAnnotation).
MGP	metacluster_22.33	MAFK (inferredBy_Orthology).
MGP	jaspar__MA1724.1	RFX6 (inferredBy_Orthology).
MGP	jaspar__MA1105.2	GRHL2 (directAnnotation).
MGP	transfac_pro__M06292	ZNF766 (directAnnotation).
MGP	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MGP	"Calcium"	DB01373	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."