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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MFN2

Summary for MFN2

Gene information	Gene symbol	MFN2
	Ensembl ID	ENSG00000116688
	Entrez ID	9927
	Gene name	mitofusin 2
	Synonyms	CMT2A2\|CPRP1\|KIAA0214\|MARF
	Gene type	protein_coding
	UniProtAcc	O95140

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Dataset with differentially expressed gene: MFN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.335318	0.00e+00

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Expression of MFN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MFN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MFN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MFN2	hsa-miR-3619-5p	97.501	NM_001127660
MFN2	hsa-miR-214-3p	96.9031	NM_001127660
MFN2	hsa-miR-761	96.9031	NM_001127660
MFN2	hsa-miR-766-3p	96.3262	NM_001127660
MFN2	hsa-miR-4437	94.0009	NM_001127660
MFN2	hsa-miR-15a-5p	93.2385	NM_001127660
MFN2	hsa-miR-6838-5p	93.2385	NM_001127660
MFN2	hsa-miR-15b-5p	93.2385	NM_001127660
MFN2	hsa-miR-16-5p	93.2385	NM_001127660
MFN2	hsa-miR-195-5p	93.2385	NM_001127660
MFN2	hsa-miR-497-5p	91.559	NM_001127660
MFN2	hsa-miR-424-5p	91.559	NM_001127660
MFN2	hsa-miR-625-5p	91.3571	NM_001127660
MFN2	hsa-miR-6829-5p	90.484	NM_001127660
MFN2	hsa-miR-499a-3p	88.4977	NM_001127660
MFN2	hsa-miR-499b-3p	88.4977	NM_001127660
MFN2	hsa-miR-106b-5p	88.2608	NM_001127660
MFN2	hsa-miR-20a-5p	88.2608	NM_001127660
MFN2	hsa-miR-4310	88.2174	NM_001127660
MFN2	hsa-miR-7157-5p	86.6953	NM_001127660
MFN2	hsa-miR-103a-3p	86.5841	NM_001127660
MFN2	hsa-miR-107	86.5841	NM_001127660
MFN2	hsa-miR-4447	85.3133	NM_001127660
MFN2	hsa-miR-4291	84.6104	NM_001127660
MFN2	hsa-miR-519d-3p	84.2163	NM_001127660
MFN2	hsa-miR-17-5p	84.2163	NM_001127660
MFN2	hsa-miR-526b-3p	84.2163	NM_001127660
MFN2	hsa-miR-20b-5p	84.2163	NM_001127660
MFN2	hsa-miR-93-5p	84.2163	NM_001127660
MFN2	hsa-miR-106a-5p	84.2163	NM_001127660
MFN2	hsa-miR-6751-5p	81.3635	NM_001127660
MFN2	hsa-miR-302e	81.2476	NM_001127660
MFN2	hsa-miR-3194-3p	81.1456	NM_001127660
MFN2	hsa-miR-4721	80.4021	NM_001127660
MFN2	hsa-miR-1275	80.3032	NM_001127660

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Motifs and transcription factors (TFs) regulating MFN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MFN2	metacluster_7.13	ZFX (directAnnotation).
MFN2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MFN2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MFN2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MFN2	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."