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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MFHAS1

Summary for MFHAS1

Gene information	Gene symbol	MFHAS1
	Ensembl ID	ENSG00000147324
	Entrez ID	9258
	Gene name	multifunctional ROCO family signaling regulator 1
	Synonyms	LRRC65\|MASL1
	Gene type	protein_coding
	UniProtAcc	Q9Y4C4

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Dataset with differentially expressed gene: MFHAS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.387367	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.386941	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.745399	0.00e+00

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Expression of MFHAS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MFHAS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MFHAS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MFHAS1	hsa-miR-627-3p	98.5139	NM_004225
MFHAS1	hsa-miR-7162-3p	97.4528	NM_004225
MFHAS1	hsa-miR-3194-3p	96.296	NM_004225
MFHAS1	hsa-miR-1283	94.9124	NM_004225
MFHAS1	hsa-miR-6728-3p	94.298	NM_004225
MFHAS1	hsa-miR-3611	94.1272	NM_004225
MFHAS1	hsa-miR-135a-5p	94.0038	NM_004225
MFHAS1	hsa-miR-135b-5p	94.0038	NM_004225
MFHAS1	hsa-miR-6772-3p	93.4128	NM_004225
MFHAS1	hsa-miR-4319	92.8143	NM_004225
MFHAS1	hsa-miR-3136-3p	92.7134	NM_004225
MFHAS1	hsa-miR-7155-3p	92.7134	NM_004225
MFHAS1	hsa-miR-4649-3p	92.3149	NM_004225
MFHAS1	hsa-miR-4704-5p	92.1287	NM_004225
MFHAS1	hsa-miR-3680-3p	91.6841	NM_004225
MFHAS1	hsa-miR-3119	91.113	NM_004225
MFHAS1	hsa-miR-30e-5p	90.4058	NM_004225
MFHAS1	hsa-miR-30c-5p	90.4058	NM_004225
MFHAS1	hsa-miR-30a-5p	90.4058	NM_004225
MFHAS1	hsa-miR-30b-5p	90.4058	NM_004225
MFHAS1	hsa-miR-30d-5p	90.4058	NM_004225
MFHAS1	hsa-miR-340-5p	90.104	NM_004225
MFHAS1	hsa-miR-12119	90.0481	NM_004225
MFHAS1	hsa-miR-125a-5p	89.8926	NM_004225
MFHAS1	hsa-miR-125b-5p	89.8926	NM_004225
MFHAS1	hsa-miR-448	88.2853	NM_004225
MFHAS1	hsa-miR-92b-3p	88.2469	NM_004225
MFHAS1	hsa-miR-32-5p	88.2469	NM_004225
MFHAS1	hsa-miR-92a-3p	88.2469	NM_004225
MFHAS1	hsa-miR-889-5p	87.7043	NM_004225
MFHAS1	hsa-miR-6894-5p	87.0372	NM_004225
MFHAS1	hsa-miR-363-3p	85.2963	NM_004225
MFHAS1	hsa-miR-25-3p	85.2963	NM_004225
MFHAS1	hsa-miR-367-3p	85.2963	NM_004225
MFHAS1	hsa-miR-186-5p	84.8885	NM_004225
MFHAS1	hsa-miR-4716-5p	84.16	NM_004225
MFHAS1	hsa-miR-3163	83.5173	NM_004225
MFHAS1	hsa-miR-328-3p	83.0756	NM_004225
MFHAS1	hsa-miR-1297	82.5642	NM_004225
MFHAS1	hsa-miR-8066	81.9278	NM_004225
MFHAS1	hsa-miR-3612	81.7739	NM_004225
MFHAS1	hsa-miR-650	81.7739	NM_004225
MFHAS1	hsa-miR-548aj-5p	81.3852	NM_004225
MFHAS1	hsa-miR-548x-5p	81.3852	NM_004225
MFHAS1	hsa-miR-548g-5p	81.3852	NM_004225
MFHAS1	hsa-miR-548f-5p	81.3852	NM_004225
MFHAS1	hsa-miR-548c-3p	80.8086	NM_004225
MFHAS1	hsa-miR-5697	80.1651	NM_004225

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Motifs and transcription factors (TFs) regulating MFHAS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MFHAS1	metacluster_135.11	NR2C2 (directAnnotation).
MFHAS1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MFHAS1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MFHAS1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MFHAS1	cisbp__M00968	MTF2 (directAnnotation).
MFHAS1	cisbp__M00341	PAX6 (directAnnotation).
MFHAS1	metacluster_198.3	ZFP64 (directAnnotation).
MFHAS1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MFHAS1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MFHAS1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MFHAS1	cisbp__M00788	ZFY (inferredBy_Orthology).
MFHAS1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MFHAS1	hdpi__ZNF304	ZNF304 (directAnnotation).
MFHAS1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MFHAS1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MFHAS1	transfac_pro__M01199	TRIM28 (directAnnotation).
MFHAS1	metacluster_151.2	ZNF23 (directAnnotation).
MFHAS1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MFHAS1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MFHAS1	transfac_pro__M03806	ZBTB7C (directAnnotation).
MFHAS1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MFHAS1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MFHAS1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
MFHAS1	transfac_pro__M02089	E2F3 (directAnnotation).
MFHAS1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MFHAS1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MFHAS1	transfac_pro__M04817	ZBTB33 (directAnnotation).
MFHAS1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
MFHAS1	tfdimers__MD00483	ZBTB14 (directAnnotation).
MFHAS1	cisbp__M07938	E2F1 (directAnnotation).
MFHAS1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
MFHAS1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MFHAS1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MFHAS1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MFHAS1	jaspar__MA1122.1	TFDP1 (directAnnotation).
MFHAS1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."