Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MEX3A

Summary for MEX3A

Gene information	Gene symbol	MEX3A
	Ensembl ID	ENSG00000254726
	Entrez ID	92312
	Gene name	mex-3 RNA binding family member A
	Synonyms	RKHD4\|RNF162
	Gene type	protein_coding
	UniProtAcc	A1L020

Top

Dataset with differentially expressed gene: MEX3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.7937	1.10e-02
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.370464	0.00e+00

Top

Expression of MEX3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MEX3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MEX3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MEX3A	hsa-miR-4795-3p	97.2821	NM_001093725
MEX3A	hsa-miR-126-5p	96.5062	NM_001093725
MEX3A	hsa-miR-625-5p	96.4691	NM_001093725
MEX3A	hsa-miR-6756-5p	96.2097	NM_001093725
MEX3A	hsa-miR-3133	95.3779	NM_001093725
MEX3A	hsa-miR-6845-3p	95.368	NM_001093725
MEX3A	hsa-miR-29b-2-5p	94.8686	NM_001093725
MEX3A	hsa-miR-6797-5p	94.4507	NM_001093725
MEX3A	hsa-miR-6766-5p	94.3493	NM_001093725
MEX3A	hsa-miR-4284	94.2198	NM_001093725
MEX3A	hsa-miR-6887-3p	94.0089	NM_001093725
MEX3A	hsa-miR-1249-5p	93.9296	NM_001093725
MEX3A	hsa-miR-4728-5p	93.9015	NM_001093725
MEX3A	hsa-miR-365a-3p	93.4739	NM_001093725
MEX3A	hsa-miR-365b-3p	93.4739	NM_001093725
MEX3A	hsa-miR-6799-5p	93.3966	NM_001093725
MEX3A	hsa-miR-202-3p	92.7321	NM_001093725
MEX3A	hsa-miR-186-3p	92.372	NM_001093725
MEX3A	hsa-miR-944	92.292	NM_001093725
MEX3A	hsa-miR-6809-3p	92.0383	NM_001093725
MEX3A	hsa-miR-6785-5p	91.469	NM_001093725
MEX3A	hsa-miR-6833-3p	90.6631	NM_001093725
MEX3A	hsa-miR-342-3p	90.5419	NM_001093725
MEX3A	hsa-miR-149-3p	90.0929	NM_001093725
MEX3A	hsa-miR-6883-5p	90.0929	NM_001093725
MEX3A	hsa-miR-608	89.7631	NM_001093725
MEX3A	hsa-miR-4651	89.7631	NM_001093725
MEX3A	hsa-miR-4447	89.6398	NM_001093725
MEX3A	hsa-miR-628-3p	88.7663	NM_001093725
MEX3A	hsa-miR-4768-5p	87.9195	NM_001093725
MEX3A	hsa-miR-520f-3p	87.9193	NM_001093725
MEX3A	hsa-miR-6759-5p	87.5643	NM_001093725
MEX3A	hsa-miR-6722-3p	87.0786	NM_001093725
MEX3A	hsa-miR-9500	86.9088	NM_001093725
MEX3A	hsa-miR-3163	86.6978	NM_001093725
MEX3A	hsa-miR-491-5p	86.3906	NM_001093725
MEX3A	hsa-miR-5698	86.2409	NM_001093725
MEX3A	hsa-miR-6870-5p	86.2409	NM_001093725
MEX3A	hsa-miR-4723-5p	86.2409	NM_001093725
MEX3A	hsa-miR-7111-5p	86.2409	NM_001093725
MEX3A	hsa-miR-4779	86.0934	NM_001093725
MEX3A	hsa-miR-6873-3p	85.3095	NM_001093725
MEX3A	hsa-miR-4725-3p	85.2408	NM_001093725
MEX3A	hsa-miR-3159	85.0724	NM_001093725
MEX3A	hsa-miR-4667-3p	85.0711	NM_001093725
MEX3A	hsa-miR-3121-3p	84.999	NM_001093725
MEX3A	hsa-miR-541-5p	84.9593	NM_001093725
MEX3A	hsa-miR-1178-5p	83.7707	NM_001093725
MEX3A	hsa-miR-548e-5p	83.7473	NM_001093725
MEX3A	hsa-miR-6796-5p	83.4817	NM_001093725

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating MEX3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MEX3A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MEX3A	transfac_pro__M07397	ZNF148 (directAnnotation).
MEX3A	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
MEX3A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
MEX3A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MEX3A	transfac_pro__M01175	ZBTB7B (directAnnotation).
MEX3A	tfdimers__MD00151	CHURC1 (directAnnotation).
MEX3A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MEX3A	transfac_pro__M01714	KLF15 (directAnnotation).
MEX3A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
MEX3A	transfac_pro__M12604	ZNF444 (directAnnotation).
MEX3A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
MEX3A	transfac_pro__M02281	SP1 (directAnnotation).
MEX3A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."