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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: MEIS1

Summary for MEIS1

Gene information	Gene symbol	MEIS1
	Ensembl ID	ENSG00000143995
	Entrez ID	4211
	Gene name	Meis homeobox 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MEIS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.255281	0.00e+00

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Expression of MEIS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MEIS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MEIS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MEIS1	hsa-miR-1251-3p	95.9075	NM_002398
MEIS1	hsa-miR-4445-5p	94.3634	NM_002398
MEIS1	hsa-miR-3074-5p	89.7133	NM_002398
MEIS1	hsa-miR-507	88.6442	NM_002398
MEIS1	hsa-miR-557	87.7772	NM_002398
MEIS1	hsa-miR-23b-3p	87.6193	NM_002398
MEIS1	hsa-miR-23c	87.6193	NM_002398
MEIS1	hsa-miR-23a-3p	87.6193	NM_002398
MEIS1	hsa-miR-3156-3p	86.8692	NM_002398
MEIS1	hsa-miR-5583-3p	86.2016	NM_002398
MEIS1	hsa-miR-4504	85.8864	NM_002398
MEIS1	hsa-miR-4733-5p	85.292	NM_002398
MEIS1	hsa-miR-1273h-3p	83.9305	NM_002398
MEIS1	hsa-miR-3938	83.7611	NM_002398
MEIS1	hsa-miR-106a-3p	82.0563	NM_002398
MEIS1	hsa-miR-7155-5p	81.7441	NM_002398
MEIS1	hsa-miR-3065-5p	81.3845	NM_002398
MEIS1	hsa-miR-155-5p	80.7745	NM_002398
MEIS1	hsa-miR-3151-5p	80.6593	NM_002398

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Motifs and transcription factors (TFs) regulating MEIS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MEIS1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MEIS1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MEIS1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MEIS1	cisbp__M00341	PAX6 (directAnnotation).
MEIS1	tfdimers__MD00151	CHURC1 (directAnnotation).
MEIS1	transfac_pro__M01303	SP1 (directAnnotation).
MEIS1	transfac_pro__M07397	ZNF148 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
MEIS1	tfdimers__MD00363	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."