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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MEGF9

Summary for MEGF9

Gene information	Gene symbol	MEGF9
	Ensembl ID	ENSG00000106780
	Entrez ID	1955
	Gene name	multiple EGF like domains 9
	Synonyms	EGFL5
	Gene type	protein_coding
	UniProtAcc	Q9H1U4

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Dataset with differentially expressed gene: MEGF9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.297084	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.314839	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-1.19063	1.40e-45
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.452954	3.83e-20

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Expression of MEGF9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MEGF9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MEGF9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MEGF9	hsa-miR-5680	96.5232	NM_001080497
MEGF9	hsa-miR-7-5p	95.5279	NM_001080497
MEGF9	hsa-miR-520d-5p	92.5086	NM_001080497
MEGF9	hsa-miR-524-5p	92.5086	NM_001080497
MEGF9	hsa-miR-6853-3p	92.2164	NM_001080497
MEGF9	hsa-miR-548ad-3p	92.1223	NM_001080497
MEGF9	hsa-miR-3160-5p	91.3201	NM_001080497
MEGF9	hsa-miR-137-3p	90.5662	NM_001080497
MEGF9	hsa-miR-4307	90.0094	NM_001080497
MEGF9	hsa-miR-590-3p	89.248	NM_001080497
MEGF9	hsa-miR-4262	88.2384	NM_001080497
MEGF9	hsa-miR-3682-3p	88.2156	NM_001080497
MEGF9	hsa-miR-181c-5p	87.3054	NM_001080497
MEGF9	hsa-miR-181b-5p	87.3054	NM_001080497
MEGF9	hsa-miR-181d-5p	87.3054	NM_001080497
MEGF9	hsa-miR-181a-5p	87.3054	NM_001080497
MEGF9	hsa-miR-4495	87.2639	NM_001080497
MEGF9	hsa-miR-340-5p	86.7739	NM_001080497
MEGF9	hsa-miR-4718	86.6877	NM_001080497
MEGF9	hsa-miR-2681-5p	86.6166	NM_001080497
MEGF9	hsa-miR-3618	86.0705	NM_001080497
MEGF9	hsa-miR-8063	84.5135	NM_001080497
MEGF9	hsa-miR-5100	84.3178	NM_001080497
MEGF9	hsa-miR-150-3p	83.4443	NM_001080497
MEGF9	hsa-miR-494-3p	82.1765	NM_001080497
MEGF9	hsa-miR-144-3p	81.8818	NM_001080497
MEGF9	hsa-miR-3163	81.8321	NM_001080497
MEGF9	hsa-miR-8485	81.7251	NM_001080497
MEGF9	hsa-miR-6866-5p	81.4085	NM_001080497
MEGF9	hsa-miR-205-3p	81.0717	NM_001080497
MEGF9	hsa-miR-4713-5p	80.9219	NM_001080497
MEGF9	hsa-miR-6829-5p	80.8781	NM_001080497

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Motifs and transcription factors (TFs) regulating MEGF9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MEGF9	metacluster_9.47	PAX7 (inferredBy_Orthology).
MEGF9	transfac_pro__M05743	ZNF57 (directAnnotation).
MEGF9	transfac_pro__M06313	ZNF678 (directAnnotation).
MEGF9	tfdimers__MD00591	SRY; TFAP2C (directAnnotation).
MEGF9	metacluster_155.11	SPZ1 (directAnnotation).
MEGF9	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MEGF9	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MEGF9	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
MEGF9	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MEGF9	transfac_public__M00005	TFAP4 (directAnnotation).
MEGF9	hdpi__FEZF2	FEZF2 (directAnnotation).
MEGF9	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
MEGF9	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
MEGF9	dbtfbs__ZNF423_HEK293_ENCSR477OJI_merged_N1	ZNF423 (directAnnotation).
MEGF9	metacluster_80.6	ZIC4 (directAnnotation).
MEGF9	kznf__ZNF445_Imbeault2017_OM_MEME	ZNF445 (directAnnotation).
MEGF9	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MEGF9	tfdimers__MD00585	EBF1; STAT1 (directAnnotation).
MEGF9	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MEGF9	tfdimers__MD00483	ZBTB14 (directAnnotation).
MEGF9	transfac_pro__M06085	ZNF26 (directAnnotation).
MEGF9	transfac_pro__M04817	ZBTB33 (directAnnotation).
MEGF9	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MEGF9	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
MEGF9	transfac_pro__M01253	CNOT3 (directAnnotation).
MEGF9	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MEGF9	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."