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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MED23

Summary for MED23

Gene information	Gene symbol	MED23
	Ensembl ID	ENSG00000112282
	Entrez ID	9439
	Gene name	mediator complex subunit 23
	Synonyms	CRSP130\|CRSP3\|DRIP130\|MRT18\|Sur2
	Gene type	protein_coding
	UniProtAcc	Q9ULK4

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Dataset with differentially expressed gene: MED23

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	NK cells	0.387326	1.98e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.425477	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.335796	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.341007	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.328527	0.00e+00

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Expression of MED23 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MED23

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MED23

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MED23	hsa-miR-3163	99.6797	NM_004830
MED23	hsa-miR-4282	99.5952	NM_004830
MED23	hsa-miR-583	96.8706	NM_001270521
MED23	hsa-miR-224-5p	95.6355	NM_004830
MED23	hsa-miR-3942-3p	95.387	NM_004830
MED23	hsa-miR-10b-3p	94.1333	NM_004830
MED23	hsa-miR-3924	93.5783	NM_004830
MED23	hsa-miR-3679-3p	92.8475	NM_001270522
MED23	hsa-miR-628-3p	92.4881	NM_001270521
MED23	hsa-miR-6895-3p	91.4399	NM_001270522
MED23	hsa-miR-15b-3p	89.0674	NM_004830
MED23	hsa-miR-7157-3p	87.9605	NM_001270521
MED23	hsa-miR-6737-3p	87.9605	NM_001270521
MED23	hsa-miR-5008-3p	85.2217	NM_001270521
MED23	hsa-miR-1185-5p	84.8453	NM_001270521
MED23	hsa-miR-3679-5p	84.8453	NM_001270521
MED23	hsa-miR-5100	84.6138	NM_004830
MED23	hsa-miR-8063	83.396	NM_004830
MED23	hsa-miR-3972	83.07	NM_001270521
MED23	hsa-miR-1202	83.07	NM_001270521
MED23	hsa-miR-1185-1-3p	82.689	NM_004830
MED23	hsa-let-7f-2-3p	82.689	NM_004830
MED23	hsa-miR-1185-2-3p	82.689	NM_004830
MED23	hsa-miR-516a-3p	82.2053	NM_001270521
MED23	hsa-miR-7162-5p	82.2053	NM_001270521
MED23	hsa-miR-516b-3p	82.2053	NM_001270521
MED23	hsa-miR-374a-5p	81.3871	NM_004830
MED23	hsa-miR-6881-3p	81.2094	NM_001270521
MED23	hsa-miR-590-3p	80.8787	NM_004830
MED23	hsa-miR-606	80.852	NM_001270521

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Motifs and transcription factors (TFs) regulating MED23

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MED23	taipale_tf_pairs__TEAD4_ELK3_NCCGGAANNNNNNNMATWCC_CAP_repr	ELK3; TEAD4 (directAnnotation).
MED23	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MED23	jaspar__MA0748.2	YY2 (directAnnotation).
MED23	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
MED23	transfac_pro__M00430	E2F1 (directAnnotation).
MED23	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
MED23	hdpi__HIP2	UBE2K (directAnnotation).
MED23	hdpi__TIMELESS	TIMELESS (directAnnotation).
MED23	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
MED23	metacluster_191.5	SPDEF (inferredBy_Orthology).
MED23	transfac_pro__M00938	E2F1 (directAnnotation).
MED23	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MED23	hdpi__RARA	RARA (directAnnotation).
MED23	hdpi__ELF2	ELF2 (directAnnotation).
MED23	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MED23	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MED23	metacluster_151.2	ZNF23 (directAnnotation).
MED23	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MED23	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
MED23	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
MED23	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
MED23	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."