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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MED1

Summary for MED1

Gene information	Gene symbol	MED1
	Ensembl ID	ENSG00000125686
	Entrez ID	5469
	Gene name	mediator complex subunit 1
	Synonyms	CRSP1\|CRSP200\|DRIP230\|PBP\|PPARBP\|PPARGBP\|RB18A\|TRAP220\|TRIP2
	Gene type	protein_coding
	UniProtAcc	Q15648

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Dataset with differentially expressed gene: MED1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.317221	1.29e-21

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Expression of MED1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MED1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MED1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MED1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MED1	hsa-miR-96-5p	98.1372	NM_004774
MED1	hsa-miR-1271-5p	97.639	NM_004774
MED1	hsa-miR-12133	97.639	NM_004774
MED1	hsa-miR-182-5p	97.1788	NM_004774
MED1	hsa-miR-188-3p	95.1329	NM_004774
MED1	hsa-miR-4482-3p	93.9616	NM_004774
MED1	hsa-miR-3662	92.9584	NM_004774
MED1	hsa-miR-3148	92.7714	NM_004774
MED1	hsa-miR-298	92.512	NM_004774
MED1	hsa-miR-3613-3p	92.2036	NM_004774
MED1	hsa-miR-4641	91.7111	NM_004774
MED1	hsa-miR-4666b	91.4719	NM_004774
MED1	hsa-miR-6760-5p	90.9499	NM_004774
MED1	hsa-miR-548d-3p	90.9167	NM_004774
MED1	hsa-miR-548h-3p	90.9167	NM_004774
MED1	hsa-miR-548bb-3p	90.9167	NM_004774
MED1	hsa-miR-548ac	90.9167	NM_004774
MED1	hsa-miR-548z	90.9167	NM_004774
MED1	hsa-miR-561-5p	90.8761	NM_004774
MED1	hsa-miR-548ap-3p	90.5245	NM_004774
MED1	hsa-miR-548t-3p	90.5245	NM_004774
MED1	hsa-miR-548aa	90.5245	NM_004774
MED1	hsa-miR-4251	89.75	NM_004774
MED1	hsa-miR-6872-3p	89.6184	NM_004774
MED1	hsa-miR-495-3p	88.938	NM_004774
MED1	hsa-miR-5688	88.938	NM_004774
MED1	hsa-miR-888-5p	88.8384	NM_004774
MED1	hsa-miR-483-3p	88.6153	NM_004774
MED1	hsa-miR-4694-3p	88.3714	NM_004774
MED1	hsa-miR-5680	85.7638	NM_004774
MED1	hsa-miR-4667-3p	84.8504	NM_004774
MED1	hsa-miR-873-5p	84.4617	NM_004774
MED1	hsa-miR-6765-3p	84.304	NM_004774
MED1	hsa-miR-548aj-3p	84.113	NM_004774
MED1	hsa-miR-548x-3p	84.113	NM_004774
MED1	hsa-miR-146b-5p	81.8598	NM_004774
MED1	hsa-miR-146a-5p	81.8598	NM_004774
MED1	hsa-miR-7153-5p	81.8598	NM_004774
MED1	hsa-miR-548j-3p	81.6719	NM_004774
MED1	hsa-miR-548ah-3p	81.6719	NM_004774
MED1	hsa-miR-548ae-3p	81.6719	NM_004774
MED1	hsa-miR-548aq-3p	81.6719	NM_004774
MED1	hsa-miR-548am-3p	81.6719	NM_004774
MED1	hsa-miR-3685	81.4205	NM_004774
MED1	hsa-miR-488-3p	81.365	NM_004774
MED1	hsa-miR-510-3p	81.3146	NM_004774
MED1	hsa-miR-1182	81.2988	NM_004774

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Motifs and transcription factors (TFs) regulating MED1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MED1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MED1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MED1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MED1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MED1	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MED1	"Becocalcidiol"	DB04891	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."