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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ME1

Summary for ME1

Gene information	Gene symbol	ME1
	Ensembl ID	ENSG00000065833
	Entrez ID	4199
	Gene name	malic enzyme 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P48163

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Dataset with differentially expressed gene: ME1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.4715	6.44e-42
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.550843	0.00e+00

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Expression of ME1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ME1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ME1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ME1	hsa-miR-548c-3p	97.7643	NM_002395
ME1	hsa-miR-515-5p	97.4989	NM_002395
ME1	hsa-miR-519e-5p	97.4989	NM_002395
ME1	hsa-miR-3065-5p	96.5403	NM_002395
ME1	hsa-miR-559	94.4394	NM_002395
ME1	hsa-miR-208b-5p	94.2454	NM_002395
ME1	hsa-miR-208a-5p	94.2454	NM_002395
ME1	hsa-miR-151a-3p	93.9327	NM_002395
ME1	hsa-miR-3680-3p	93.5611	NM_002395
ME1	hsa-miR-7159-3p	93.3252	NM_002395
ME1	hsa-miR-30a-5p	93.1765	NM_002395
ME1	hsa-miR-30c-5p	93.1765	NM_002395
ME1	hsa-miR-30e-5p	93.1765	NM_002395
ME1	hsa-miR-30d-5p	93.1765	NM_002395
ME1	hsa-miR-30b-5p	93.1765	NM_002395
ME1	hsa-miR-548am-5p	92.6923	NM_002395
ME1	hsa-miR-548a-5p	92.6923	NM_002395
ME1	hsa-miR-548d-5p	92.6923	NM_002395
ME1	hsa-miR-548c-5p	92.6923	NM_002395
ME1	hsa-miR-548aq-5p	92.6923	NM_002395
ME1	hsa-miR-548ap-5p	92.6923	NM_002395
ME1	hsa-miR-548y	92.6923	NM_002395
ME1	hsa-miR-548o-5p	92.6923	NM_002395
ME1	hsa-miR-548ak	92.6923	NM_002395
ME1	hsa-miR-548ay-5p	92.6923	NM_002395
ME1	hsa-miR-548i	92.6923	NM_002395
ME1	hsa-miR-548b-5p	92.6923	NM_002395
ME1	hsa-miR-548bb-5p	92.6923	NM_002395
ME1	hsa-miR-548ad-5p	92.6923	NM_002395
ME1	hsa-miR-548h-5p	92.6923	NM_002395
ME1	hsa-miR-548j-5p	92.6923	NM_002395
ME1	hsa-miR-548au-5p	92.6923	NM_002395
ME1	hsa-miR-548as-5p	92.6923	NM_002395
ME1	hsa-miR-548ae-5p	92.6923	NM_002395
ME1	hsa-miR-548w	92.6923	NM_002395
ME1	hsa-miR-548ar-5p	92.6923	NM_002395
ME1	hsa-miR-548ab	92.6923	NM_002395
ME1	hsa-miR-15b-3p	91.7346	NM_002395
ME1	hsa-miR-1910-3p	90.8624	NM_002395
ME1	hsa-miR-6511a-5p	90.8624	NM_002395
ME1	hsa-miR-3658	90.3969	NM_002395
ME1	hsa-miR-4528	86.8469	NM_002395
ME1	hsa-miR-5692a	84.6414	NM_002395
ME1	hsa-miR-562	83.6721	NM_002395
ME1	hsa-miR-153-3p	83.4527	NM_002395
ME1	hsa-miR-6794-5p	82.7663	NM_002395
ME1	hsa-miR-196a-3p	82.2738	NM_002395
ME1	hsa-miR-6730-5p	82.2193	NM_002395
ME1	hsa-miR-8080	81.6849	NM_002395
ME1	hsa-miR-4324	80.6205	NM_002395

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Motifs and transcription factors (TFs) regulating ME1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ME1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ME1	tfdimers__MD00038	TFAP2C (directAnnotation).
ME1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ME1	metacluster_7.13	ZFX (directAnnotation).
ME1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ME1	cisbp__M00968	MTF2 (directAnnotation).
ME1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ME1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ME1	cisbp__M00341	PAX6 (directAnnotation).
ME1	metacluster_198.3	ZFP64 (directAnnotation).
ME1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ME1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ME1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ME1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ME1	cisbp__M00788	ZFY (inferredBy_Orthology).
ME1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ME1	metacluster_175.1	ZNF283 (directAnnotation).
ME1	hdpi__ZNF304	ZNF304 (directAnnotation).
ME1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ME1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ME1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ME1	transfac_pro__M01199	TRIM28 (directAnnotation).
ME1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ME1	metacluster_151.2	ZNF23 (directAnnotation).
ME1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ME1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ME1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ME1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ME1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ME1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ME1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ME1	cisbp__M00249	WT1 (directAnnotation).
ME1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ME1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ME1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ME1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ME1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ME1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
ME1	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ME1	"NADH"	DB00157	small molecule
ME1	"Nicotinamide adenine dinucleotide phosphate"	DB03461	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."