Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MDN1

Summary for MDN1

Gene information	Gene symbol	MDN1
	Ensembl ID	ENSG00000288121
	Entrez ID	23195
	Gene name	midasin AAA ATPase 1
	Synonyms	KIAA0301\|Rea1
	Gene type	protein_coding
	UniProtAcc	Q9NU22

Top

Dataset with differentially expressed gene: MDN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.22194	2.24e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.259943	2.09e-13

Top

Expression of MDN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MDN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MDN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MDN1	hsa-miR-153-3p	94.4887	NM_014611
MDN1	hsa-miR-3190-5p	93.3217	NM_014611
MDN1	hsa-miR-128-3p	91.564	NM_014611
MDN1	hsa-miR-216a-3p	91.564	NM_014611
MDN1	hsa-miR-3662	91.349	NM_014611
MDN1	hsa-miR-1297	90.2757	NM_014611
MDN1	hsa-miR-3681-3p	89.2241	NM_014611
MDN1	hsa-miR-3148	87.7116	NM_014611
MDN1	hsa-miR-26b-5p	87.46	NM_014611
MDN1	hsa-miR-26a-5p	87.46	NM_014611
MDN1	hsa-miR-6810-3p	87.042	NM_014611
MDN1	hsa-miR-633	85.868	NM_014611
MDN1	hsa-miR-6801-3p	85.5214	NM_014611
MDN1	hsa-miR-11181-5p	85.511	NM_014611
MDN1	hsa-miR-4256	85.511	NM_014611
MDN1	hsa-miR-4307	85.3201	NM_014611
MDN1	hsa-miR-27a-3p	84.9252	NM_014611
MDN1	hsa-miR-27b-3p	84.9252	NM_014611
MDN1	hsa-miR-9985	84.9252	NM_014611
MDN1	hsa-miR-1302	84.8374	NM_014611
MDN1	hsa-miR-208b-5p	83.8315	NM_014611
MDN1	hsa-miR-208a-5p	83.8315	NM_014611
MDN1	hsa-miR-4465	83.8204	NM_014611
MDN1	hsa-miR-4298	82.7904	NM_014611
MDN1	hsa-miR-4282	80.5087	NM_014611

Page: 1

Top

Motifs and transcription factors (TFs) regulating MDN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MDN1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."