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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MDM2

Summary for MDM2

Gene information	Gene symbol	MDM2
	Ensembl ID	ENSG00000135679
	Entrez ID	4193
	Gene name	MDM2 proto-oncogene
	Synonyms	HDM2\|MGC5370
	Gene type	protein_coding
	UniProtAcc	Q00987

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Dataset with differentially expressed gene: MDM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.605477	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.422228	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.513054	0.00e+00

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Expression of MDM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MDM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MDM2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MDM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MDM2	hsa-miR-3613-3p	99.56	NM_001145339
MDM2	hsa-miR-616-5p	98.703	NM_001145339
MDM2	hsa-miR-373-5p	98.703	NM_001145339
MDM2	hsa-miR-371b-5p	98.703	NM_001145339
MDM2	hsa-miR-3658	98.5517	NM_001145339
MDM2	hsa-miR-1305	98.4625	NM_001145339
MDM2	hsa-miR-548as-3p	97.2511	NM_001145339
MDM2	hsa-miR-495-3p	96.4517	NM_001145339
MDM2	hsa-miR-5688	96.4517	NM_001145339
MDM2	hsa-miR-5692a	94.9237	NM_001145337
MDM2	hsa-miR-551b-5p	94.8773	NM_001145339
MDM2	hsa-miR-6809-3p	93.0513	NM_001145339
MDM2	hsa-miR-7110-3p	92.9632	NM_001145339
MDM2	hsa-miR-4753-3p	90.4524	NM_001145339
MDM2	hsa-miR-548c-3p	90.1555	NM_001145339
MDM2	hsa-miR-4729	90.15	NM_001145337
MDM2	hsa-miR-7977	87.4718	NM_001145339
MDM2	hsa-miR-6728-3p	86.7604	NM_001145339
MDM2	hsa-miR-379-5p	86.4506	NM_001145339
MDM2	hsa-miR-660-5p	86.3429	NM_001145339
MDM2	hsa-miR-1827	85.324	NM_001145339
MDM2	hsa-miR-4528	84.5802	NM_001145339
MDM2	hsa-miR-6083	84.2949	NM_001145339
MDM2	hsa-miR-4698	83.5271	NM_001145339
MDM2	hsa-miR-224-5p	82.7479	NM_001145339
MDM2	hsa-miR-4478	82.5136	NM_001145339
MDM2	hsa-miR-3145-5p	82.4361	NM_001145339
MDM2	hsa-miR-6873-3p	81.6059	NM_001145339
MDM2	hsa-miR-5571-5p	81.5817	NM_001145339
MDM2	hsa-miR-3529-5p	81.3816	NM_001145339
MDM2	hsa-miR-190a-3p	81.2223	NM_001145339

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Motifs and transcription factors (TFs) regulating MDM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MDM2	metacluster_135.11	NR2C2 (directAnnotation).
MDM2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MDM2	metacluster_7.13	ZFX (directAnnotation).
MDM2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MDM2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
MDM2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
MDM2	cisbp__M00788	ZFY (inferredBy_Orthology).
MDM2	hdpi__ZNF304	ZNF304 (directAnnotation).
MDM2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MDM2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MDM2	transfac_pro__M01199	TRIM28 (directAnnotation).
MDM2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MDM2	transfac_pro__M03806	ZBTB7C (directAnnotation).
MDM2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MDM2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MDM2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MDM2	transfac_pro__M04918	EGR1 (directAnnotation).
MDM2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MDM2	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
MDM2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MDM2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MDM2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MDM2	transfac_pro__M01253	CNOT3 (directAnnotation).
MDM2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
MDM2	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
MDM2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
MDM2	transfac_pro__M07310	SP5 (directAnnotation).
MDM2	transfac_pro__M00938	E2F1 (directAnnotation).
MDM2	transfac_pro__M04817	ZBTB33 (directAnnotation).
MDM2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
MDM2	transfac_pro__M12697	ZNF142 (directAnnotation).
MDM2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
MDM2	transfac_pro__M04916	TAF1 (directAnnotation).
MDM2	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
MDM2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MDM2	tfdimers__MD00483	ZBTB14 (directAnnotation).
MDM2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MDM2	transfac_pro__M01303	SP1 (directAnnotation).
MDM2	metacluster_143.13	ZBTB7A (directAnnotation).
MDM2	transfac_pro__M07387	ZBTB7A (directAnnotation).
MDM2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MDM2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MDM2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MDM2	transfac_pro__M02898	SMAD3 (directAnnotation).
MDM2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
MDM2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
MDM2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
MDM2	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
MDM2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MDM2	"Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyet	DB02872	small molecule
MDM2	"Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin	DB04144	small molecule
MDM2	"Zinc acetate"	DB14487	small molecule
MDM2	"Zinc chloride"	DB14533	small molecule
MDM2	"Zinc sulfate, unspecified form"	DB14548	small molecule
MDM2	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."