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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MDM1

Summary for MDM1

Gene information	Gene symbol	MDM1
	Ensembl ID	ENSG00000111554
	Entrez ID	56890
	Gene name	Mdm1 nuclear protein
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MDM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.488977	0.00e+00

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Expression of MDM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MDM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MDM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MDM1	hsa-miR-1305	96.788	NM_001205029
MDM1	hsa-miR-545-3p	96.6762	NM_017440
MDM1	hsa-miR-607	96.2259	NM_017440
MDM1	hsa-miR-3618	95.2281	NM_017440
MDM1	hsa-miR-4305	94.8434	NM_017440
MDM1	hsa-miR-4775	93.9216	NM_001205029
MDM1	hsa-miR-619-5p	93.8715	NM_017440
MDM1	hsa-miR-6506-5p	93.8715	NM_017440
MDM1	hsa-miR-647	93.1453	NM_001205029
MDM1	hsa-miR-1283	92.9938	NM_001205029
MDM1	hsa-miR-892c-5p	92.5154	NM_001205029
MDM1	hsa-miR-326	91.4709	NM_017440
MDM1	hsa-miR-590-3p	91.0932	NM_001205029
MDM1	hsa-miR-330-5p	91.0713	NM_017440
MDM1	hsa-miR-1272	90.7455	NM_020128
MDM1	hsa-miR-8063	90.1692	NM_017440
MDM1	hsa-miR-1185-2-3p	89.7443	NM_017440
MDM1	hsa-miR-1185-1-3p	89.7443	NM_017440
MDM1	hsa-let-7f-2-3p	89.7443	NM_017440
MDM1	hsa-miR-136-5p	89.7243	NM_017440
MDM1	hsa-miR-3613-3p	89.6758	NM_017440
MDM1	hsa-miR-11181-3p	88.5268	NM_001205029
MDM1	hsa-miR-200a-3p	88.4646	NM_017440
MDM1	hsa-miR-141-3p	88.4646	NM_017440
MDM1	hsa-miR-765	87.9702	NM_001205029
MDM1	hsa-miR-5571-5p	87.5043	NM_017440
MDM1	hsa-miR-6840-3p	87.1389	NM_020128
MDM1	hsa-miR-4698	85.9894	NM_017440
MDM1	hsa-miR-4668-3p	85.1429	NM_001205029
MDM1	hsa-miR-6824-5p	85.0058	NM_017440
MDM1	hsa-miR-19a-3p	84.7368	NM_020128
MDM1	hsa-miR-19b-3p	84.7368	NM_020128
MDM1	hsa-miR-548at-5p	84.7055	NM_017440
MDM1	hsa-miR-5000-5p	83.9848	NM_001205029
MDM1	hsa-miR-8070	83.684	NM_001205029
MDM1	hsa-miR-26b-3p	82.4406	NM_017440
MDM1	hsa-miR-6885-3p	82.4292	NM_001205029
MDM1	hsa-miR-505-3p	82.3788	NM_001205029
MDM1	hsa-miR-340-5p	81.9697	NM_017440
MDM1	hsa-miR-6842-3p	81.522	NM_001205029
MDM1	hsa-miR-24-1-5p	81.3316	NM_001205029
MDM1	hsa-miR-24-2-5p	81.3316	NM_001205029
MDM1	hsa-miR-548e-5p	81.1727	NM_001205029
MDM1	hsa-miR-373-5p	80.9493	NM_017440
MDM1	hsa-miR-616-5p	80.9493	NM_017440
MDM1	hsa-miR-371b-5p	80.9493	NM_017440
MDM1	hsa-miR-5680	80.9434	NM_001205029
MDM1	hsa-miR-134-3p	80.8484	NM_001205029
MDM1	hsa-miR-676-5p	80.8074	NM_020128
MDM1	hsa-miR-12123	80.4498	NM_017440

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Motifs and transcription factors (TFs) regulating MDM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MDM1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MDM1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MDM1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MDM1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MDM1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MDM1	transfac_pro__M02089	E2F3 (directAnnotation).
MDM1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MDM1	cisbp__M07938	E2F1 (directAnnotation).
MDM1	transfac_pro__M02898	SMAD3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."