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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MCUR1

Summary for MCUR1

Gene information	Gene symbol	MCUR1
	Ensembl ID	ENSG00000050393
	Entrez ID	63933
	Gene name	mitochondrial calcium uniporter regulator 1
	Synonyms	C6orf79\|CCDC90A\|FLJ20958
	Gene type	protein_coding
	UniProtAcc	Q96AQ8

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Dataset with differentially expressed gene: MCUR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.749058	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.286071	4.21e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.334659	6.09e-17
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.323991	1.61e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.281958	0.00e+00

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Expression of MCUR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MCUR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MCUR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MCUR1	hsa-miR-4437	96.8036	NM_001031713
MCUR1	hsa-miR-372-5p	96.3589	NM_001031713
MCUR1	hsa-miR-12120	95.2567	NM_001031713
MCUR1	hsa-miR-4282	89.4931	NM_001031713
MCUR1	hsa-miR-1297	89.1422	NM_001031713
MCUR1	hsa-miR-4777-5p	88.9317	NM_001031713
MCUR1	hsa-miR-4775	88.0625	NM_001031713
MCUR1	hsa-miR-6780b-3p	87.3583	NM_001031713
MCUR1	hsa-miR-26a-5p	86.9045	NM_001031713
MCUR1	hsa-miR-26b-5p	86.9045	NM_001031713
MCUR1	hsa-miR-5581-3p	86.889	NM_001031713
MCUR1	hsa-miR-6842-3p	86.7912	NM_001031713
MCUR1	hsa-miR-3652	86.2625	NM_001031713
MCUR1	hsa-miR-4430	86.2625	NM_001031713
MCUR1	hsa-miR-383-5p	85.5819	NM_001031713
MCUR1	hsa-miR-3714	85.4965	NM_001031713
MCUR1	hsa-miR-6885-3p	85.1259	NM_001031713
MCUR1	hsa-miR-335-3p	84.4179	NM_001031713
MCUR1	hsa-miR-10393-5p	84.1621	NM_001031713
MCUR1	hsa-miR-4465	83.758	NM_001031713
MCUR1	hsa-miR-511-3p	83.5997	NM_001031713
MCUR1	hsa-miR-493-5p	83.4312	NM_001031713
MCUR1	hsa-miR-506-3p	83.2329	NM_001031713
MCUR1	hsa-miR-124-3p	83.2329	NM_001031713
MCUR1	hsa-miR-3658	83.0916	NM_001031713
MCUR1	hsa-miR-6778-3p	82.9155	NM_001031713
MCUR1	hsa-miR-3616-3p	81.6512	NM_001031713
MCUR1	hsa-miR-6817-3p	81.5053	NM_001031713
MCUR1	hsa-miR-1468-3p	80.844	NM_001031713
MCUR1	hsa-miR-12136	80.2382	NM_001031713

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Motifs and transcription factors (TFs) regulating MCUR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MCUR1	metacluster_7.13	ZFX (directAnnotation).
MCUR1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MCUR1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MCUR1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MCUR1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MCUR1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MCUR1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MCUR1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MCUR1	transfac_pro__M04866	HDAC2 (directAnnotation).
MCUR1	jaspar__MA1122.1	TFDP1 (directAnnotation).
MCUR1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MCUR1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
MCUR1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
MCUR1	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
MCUR1	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."