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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MCU

Summary for MCU

Gene information	Gene symbol	MCU
	Ensembl ID	ENSG00000156026
	Entrez ID	90550
	Gene name	mitochondrial calcium uniporter
	Synonyms	C10orf42\|CCDC109A\|FLJ46135
	Gene type	protein_coding
	UniProtAcc	Q8NE86

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Dataset with differentially expressed gene: MCU

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.446637	0.00e+00

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Expression of MCU in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MCU

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MCU

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MCU	hsa-miR-548z	94.9793	NM_001270679
MCU	hsa-miR-548ac	94.9793	NM_001270679
MCU	hsa-miR-548bb-3p	94.9793	NM_001270679
MCU	hsa-miR-548h-3p	94.9793	NM_001270679
MCU	hsa-miR-548d-3p	94.9793	NM_001270679
MCU	hsa-miR-4650-3p	94.0211	NM_001270679
MCU	hsa-miR-6891-5p	93.1356	NM_001270679
MCU	hsa-miR-3173-3p	93.1356	NM_001270679
MCU	hsa-miR-12118	93.1356	NM_001270679
MCU	hsa-miR-548aj-3p	91.5179	NM_001270679
MCU	hsa-miR-548x-3p	91.5179	NM_001270679
MCU	hsa-miR-3613-3p	88.1111	NM_001270679
MCU	hsa-miR-548am-3p	88.0185	NM_001270679
MCU	hsa-miR-548ah-3p	88.0185	NM_001270679
MCU	hsa-miR-548j-3p	88.0185	NM_001270679
MCU	hsa-miR-548aq-3p	88.0185	NM_001270679
MCU	hsa-miR-548ae-3p	88.0185	NM_001270679
MCU	hsa-miR-15a-5p	87.178	NM_001270679
MCU	hsa-miR-15b-5p	87.178	NM_001270679
MCU	hsa-miR-16-5p	87.178	NM_001270679
MCU	hsa-miR-195-5p	87.178	NM_001270679
MCU	hsa-miR-3650	86.2972	NM_001270679
MCU	hsa-miR-501-5p	85.2948	NM_001270679
MCU	hsa-miR-3148	85.2602	NM_138357
MCU	hsa-miR-1915-5p	84.0654	NM_138357
MCU	hsa-miR-1252-3p	83.2861	NM_138357
MCU	hsa-miR-3064-3p	82.0282	NM_138357
MCU	hsa-miR-499a-5p	81.8548	NM_001270679
MCU	hsa-miR-7-1-3p	81.8238	NM_001270679
MCU	hsa-miR-7-2-3p	81.8238	NM_001270679
MCU	hsa-miR-1299	81.7169	NM_138357
MCU	hsa-miR-497-5p	81.5446	NM_001270679
MCU	hsa-miR-424-5p	81.5446	NM_001270679
MCU	hsa-miR-485-3p	81.5021	NM_001270679
MCU	hsa-miR-539-3p	81.5021	NM_001270679
MCU	hsa-miR-6809-3p	81.4554	NM_138357
MCU	hsa-miR-6838-5p	81.1182	NM_001270679
MCU	hsa-miR-340-5p	80.8966	NM_138357
MCU	hsa-miR-208a-3p	80.5764	NM_001270679
MCU	hsa-miR-208b-3p	80.5764	NM_001270679

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Motifs and transcription factors (TFs) regulating MCU

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MCU	metacluster_175.1	ZNF283 (directAnnotation).
MCU	metacluster_151.2	ZNF23 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."