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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MCTP2

Summary for MCTP2

Gene information	Gene symbol	MCTP2
	Ensembl ID	ENSG00000140563
	Entrez ID	55784
	Gene name	multiple C2 and transmembrane domain containing 2
	Synonyms	FLJ11175\|FLJ33303
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MCTP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.261868	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.297228	4.97e-09

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Expression of MCTP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MCTP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MCTP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MCTP2	hsa-miR-374a-5p	98.4393	NM_001159643
MCTP2	hsa-miR-374b-5p	98.1036	NM_001159643
MCTP2	hsa-miR-335-3p	97.3397	NM_001159643
MCTP2	hsa-miR-4742-5p	97.1015	NM_001159643
MCTP2	hsa-miR-4766-5p	95.6902	NM_001159643
MCTP2	hsa-miR-297	94.4018	NM_001159643
MCTP2	hsa-miR-5692c	93.5143	NM_001159643
MCTP2	hsa-miR-5692b	93.5143	NM_001159643
MCTP2	hsa-miR-4699-5p	93.3235	NM_001159643
MCTP2	hsa-miR-664b-5p	93.1496	NM_001159644
MCTP2	hsa-miR-379-5p	92.4231	NM_001159644
MCTP2	hsa-miR-513c-5p	91.9547	NM_001159643
MCTP2	hsa-miR-5696	90.8988	NM_001159643
MCTP2	hsa-miR-3529-5p	90.674	NM_001159644
MCTP2	hsa-miR-1305	89.9036	NM_001159643
MCTP2	hsa-miR-3679-3p	89.3789	NM_001159644
MCTP2	hsa-miR-3613-3p	88.9178	NM_001159643
MCTP2	hsa-miR-1250-3p	88.8657	NM_001159643
MCTP2	hsa-miR-205-3p	88.1053	NM_001159643
MCTP2	hsa-miR-514b-5p	87.9408	NM_001159643
MCTP2	hsa-miR-874-3p	87.9161	NM_001159644
MCTP2	hsa-miR-6780a-3p	87.9079	NM_001159643
MCTP2	hsa-miR-1252-3p	87.7494	NM_001159643
MCTP2	hsa-miR-1301-3p	87.7467	NM_001159643
MCTP2	hsa-miR-5047	87.7467	NM_001159643
MCTP2	hsa-miR-10527-5p	87.6372	NM_001159643
MCTP2	hsa-miR-4319	86.7943	NM_001159644
MCTP2	hsa-miR-4753-5p	86.6913	NM_001159644
MCTP2	hsa-miR-5692a	86.2522	NM_001159643
MCTP2	hsa-miR-4490	85.8372	NM_001159643
MCTP2	hsa-miR-4666a-3p	85.2841	NM_001159643
MCTP2	hsa-miR-944	84.2449	NM_001159643
MCTP2	hsa-miR-922	83.5275	NM_001159644
MCTP2	hsa-miR-4672	83.4824	NM_001159643
MCTP2	hsa-miR-4695-3p	82.7192	NM_001159643
MCTP2	hsa-miR-543	82.7124	NM_001159644
MCTP2	hsa-miR-125a-5p	82.6329	NM_001159644
MCTP2	hsa-miR-125b-5p	82.6329	NM_001159644
MCTP2	hsa-miR-196b-3p	82.0506	NM_001159644
MCTP2	hsa-miR-153-5p	81.964	NM_001159643
MCTP2	hsa-miR-3671	81.8036	NM_001159643
MCTP2	hsa-miR-6867-5p	81.7854	NM_001159643
MCTP2	hsa-miR-3149	81.7135	NM_001159643
MCTP2	hsa-miR-3972	81.6206	NM_001159643

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Motifs and transcription factors (TFs) regulating MCTP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MCTP2	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."