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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MCC

Summary for MCC

Gene information	Gene symbol	MCC
	Ensembl ID	ENSG00000171444
	Entrez ID	4163
	Gene name	MCC regulator of WNT signaling pathway
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P23508

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Dataset with differentially expressed gene: MCC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.796913	2.69e-04
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.318198	0.00e+00

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Expression of MCC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MCC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MCC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MCC	hsa-miR-548f-3p	97.3985	NM_001085377
MCC	hsa-miR-548az-3p	97.3985	NM_001085377
MCC	hsa-miR-548a-3p	97.3985	NM_001085377
MCC	hsa-miR-548bc	97.3985	NM_001085377
MCC	hsa-miR-548e-3p	97.3985	NM_001085377
MCC	hsa-miR-548ar-3p	97.1912	NM_001085377
MCC	hsa-miR-892c-5p	97.1824	NM_001085377
MCC	hsa-miR-3671	96.1922	NM_001085377
MCC	hsa-miR-7114-5p	95.025	NM_001085377
MCC	hsa-miR-624-3p	94.6734	NM_001085377
MCC	hsa-miR-4261	94.3148	NM_001085377
MCC	hsa-miR-7-2-3p	93.0695	NM_001085377
MCC	hsa-miR-7-1-3p	93.0695	NM_001085377
MCC	hsa-miR-593-3p	92.7617	NM_001085377
MCC	hsa-miR-302e	92.6918	NM_001085377
MCC	hsa-miR-4503	91.9619	NM_001085377
MCC	hsa-miR-186-5p	91.5692	NM_001085377
MCC	hsa-miR-6513-3p	91.3695	NM_001085377
MCC	hsa-miR-147b-5p	90.667	NM_001085377
MCC	hsa-miR-302d-3p	90.3703	NM_001085377
MCC	hsa-miR-302a-3p	90.3703	NM_001085377
MCC	hsa-miR-302c-3p	90.3703	NM_001085377
MCC	hsa-miR-302b-3p	90.3703	NM_001085377
MCC	hsa-miR-450b-5p	89.7299	NM_001085377
MCC	hsa-miR-625-5p	89.3066	NM_001085377
MCC	hsa-miR-527	88.5661	NM_001085377
MCC	hsa-miR-518a-5p	88.5661	NM_001085377
MCC	hsa-miR-6077	88.2796	NM_001085377
MCC	hsa-miR-562	87.701	NM_001085377
MCC	hsa-miR-520d-3p	87.108	NM_001085377
MCC	hsa-miR-372-3p	87.108	NM_001085377
MCC	hsa-miR-520b-3p	87.108	NM_001085377
MCC	hsa-miR-520c-3p	87.108	NM_001085377
MCC	hsa-miR-520a-3p	87.108	NM_001085377
MCC	hsa-miR-520e-3p	87.108	NM_001085377
MCC	hsa-miR-373-3p	87.0978	NM_001085377
MCC	hsa-miR-4262	86.4542	NM_001085377
MCC	hsa-miR-568	86.2172	NM_001085377
MCC	hsa-miR-8068	85.9507	NM_001085377
MCC	hsa-miR-589-3p	85.8499	NM_001085377
MCC	hsa-miR-548aj-3p	83.919	NM_001085377
MCC	hsa-miR-548x-3p	83.919	NM_001085377
MCC	hsa-miR-3157-5p	83.9164	NM_001085377
MCC	hsa-miR-6715b-5p	83.2008	NM_001085377
MCC	hsa-miR-6818-3p	82.9991	NM_001085377
MCC	hsa-miR-181d-5p	82.8848	NM_001085377
MCC	hsa-miR-181b-5p	82.8848	NM_001085377
MCC	hsa-miR-181a-5p	82.8848	NM_001085377
MCC	hsa-miR-181c-5p	82.8848	NM_001085377
MCC	hsa-miR-4310	82.6307	NM_001085377

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Motifs and transcription factors (TFs) regulating MCC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MCC	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
MCC	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MCC	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MCC	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
MCC	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MCC	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."