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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MBD6

Summary for MBD6

Gene information	Gene symbol	MBD6
	Ensembl ID	ENSG00000166987
	Entrez ID	114785
	Gene name	methyl-CpG binding domain protein 6
	Synonyms	KIAA1887
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MBD6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.274918	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.40149	7.12e-43

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Expression of MBD6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MBD6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MBD6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MBD6	hsa-miR-2113	98.7259	NM_052897
MBD6	hsa-miR-6852-5p	97.7827	NM_052897
MBD6	hsa-miR-4267	93.9049	NM_052897
MBD6	hsa-miR-6751-3p	93.5217	NM_052897
MBD6	hsa-miR-1199-5p	93.2725	NM_052897
MBD6	hsa-miR-3921	92.4356	NM_052897
MBD6	hsa-miR-4653-5p	92.4356	NM_052897
MBD6	hsa-miR-4725-3p	91.8671	NM_052897
MBD6	hsa-miR-6780b-5p	91.8671	NM_052897
MBD6	hsa-miR-7157-3p	91.8474	NM_052897
MBD6	hsa-miR-6737-3p	91.8474	NM_052897
MBD6	hsa-miR-6736-3p	91.7734	NM_052897
MBD6	hsa-miR-3975	91.7555	NM_052897
MBD6	hsa-miR-302a-5p	91.4736	NM_052897
MBD6	hsa-miR-650	89.489	NM_052897
MBD6	hsa-miR-3612	89.489	NM_052897
MBD6	hsa-miR-4747-5p	89.3207	NM_052897
MBD6	hsa-miR-5196-5p	89.3207	NM_052897
MBD6	hsa-miR-4271	88.8965	NM_052897
MBD6	hsa-miR-19a-3p	88.8558	NM_052897
MBD6	hsa-miR-19b-3p	88.8558	NM_052897
MBD6	hsa-miR-5008-3p	88.8381	NM_052897
MBD6	hsa-miR-5087	88.7261	NM_052897
MBD6	hsa-miR-7851-3p	88.622	NM_052897
MBD6	hsa-miR-511-5p	88.6061	NM_052897
MBD6	hsa-miR-653-3p	88.2092	NM_052897
MBD6	hsa-miR-24-3p	88.1289	NM_052897
MBD6	hsa-miR-6814-5p	88.0563	NM_052897
MBD6	hsa-miR-142-3p	86.7649	NM_052897
MBD6	hsa-miR-4481	86.0851	NM_052897
MBD6	hsa-miR-4745-5p	85.8704	NM_052897
MBD6	hsa-miR-648	85.7798	NM_052897
MBD6	hsa-miR-150-5p	85.7211	NM_052897
MBD6	hsa-miR-6783-5p	84.9109	NM_052897
MBD6	hsa-miR-4640-3p	84.7151	NM_052897
MBD6	hsa-miR-135a-2-3p	82.9902	NM_052897
MBD6	hsa-miR-135b-3p	82.9902	NM_052897
MBD6	hsa-miR-2116-3p	81.578	NM_052897
MBD6	hsa-miR-92a-2-5p	80.8736	NM_052897
MBD6	hsa-miR-4700-5p	80.5736	NM_052897
MBD6	hsa-miR-4667-5p	80.5736	NM_052897
MBD6	hsa-miR-7109-5p	80.1394	NM_052897

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Motifs and transcription factors (TFs) regulating MBD6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MBD6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MBD6	jaspar__MA1483.2	ELF2 (directAnnotation).
MBD6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MBD6	transfac_pro__M05628	ZNF735 (directAnnotation).
MBD6	jaspar__MA0079.5	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."