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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor

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Acts as a drug target< (This gene does not contain this module)

Gene: MAX

Summary for MAX

Gene informationGene symbol

MAX

Ensembl ID

ENSG00000125952

Entrez ID

4149

Gene nameMYC associated factor X
SynonymsbHLHd4|bHLHd5|bHLHd6|bHLHd7|bHLHd8
Gene typeprotein_coding
UniProtAcc

P61244


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Dataset with differentially expressed gene: MAX

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.2577450.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD8+ T cells0.2809017.43e-05

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.2528917.14e-28

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Expression of MAX in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to MAX

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAX

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
MAXhsa-miR-10b-3p99.0377NM_145113
MAXhsa-miR-616595.4964NM_145113
MAXhsa-miR-469695.09NM_145113
MAXhsa-miR-651-3p93.8131NM_145112
MAXhsa-miR-130393.477NM_145114
MAXhsa-miR-314893.2611NM_145112
MAXhsa-miR-3173-3p92.9564NM_145112
MAXhsa-miR-6891-5p92.9564NM_145112
MAXhsa-miR-1211892.9564NM_145112
MAXhsa-miR-1212490.9452NM_145113
MAXhsa-miR-22-3p90.7601NM_145113
MAXhsa-miR-6878-5p89.2781NM_145112
MAXhsa-miR-548c-3p89.0385NM_145113
MAXhsa-miR-805788.997NM_145112
MAXhsa-miR-472188.921NM_145112
MAXhsa-miR-20688.8986NM_145113
MAXhsa-miR-1-3p88.8986NM_145113
MAXhsa-miR-425787.9161NM_145113
MAXhsa-miR-452787.7192NM_145113
MAXhsa-miR-6721-5p86.4194NM_145112
MAXhsa-miR-46686.2941NM_145114
MAXhsa-miR-4704-5p86.0962NM_145112
MAXhsa-miR-751585.014NM_145113
MAXhsa-miR-61384.2452NM_145113
MAXhsa-miR-3617-5p83.9421NM_145114
MAXhsa-miR-64183.9421NM_145114
MAXhsa-miR-6753-5p83.0416NM_145114
MAXhsa-miR-428282.8731NM_145112
MAXhsa-miR-6503-5p82.4866NM_145113
MAXhsa-miR-806582.4585NM_145112
MAXhsa-miR-6747-5p82.3851NM_145112
MAXhsa-miR-397282.1422NM_145114
MAXhsa-miR-120282.1422NM_145114
MAXhsa-miR-568081.7431NM_145113
MAXhsa-miR-4715-3p81.6799NM_197957
MAXhsa-miR-316380.9364NM_145113
MAXhsa-miR-659-3p80.8173NM_145113
MAXhsa-miR-624-5p80.3883NM_145113
MAXhsa-miR-10526-3p80.0809NM_145113
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Motifs and transcription factors (TFs) regulating MAX

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
MAXmetacluster_34.4ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
MAXjaspar__MA1483.2ELF2 (directAnnotation).
MAXmetacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
MAXtaipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAPETV5; FOXI1 (directAnnotation).
MAXcisbp__M08198ELF1 (directAnnotation).
MAXtaipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_reprDRGX; ETV2 (directAnnotation).
MAXtaipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAPELK1; FOXI1 (directAnnotation).
MAXhocomoco__TYY2_HUMAN.H11MO.0.DYY2 (directAnnotation).
MAXmetacluster_141.4GLIS2 (directAnnotation).
MAXtransfac_pro__M04861SIX5 (directAnnotation).
MAXhdpi__FLI1FLI1 (directAnnotation).
MAXmetacluster_160.20JUND; PRDM15 (directAnnotation).
MAXjaspar__MA0185.1DEAF1 (inferredBy_Orthology).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.
TFmotifExpressionCell typeDatasetTimepoint
MAXtaipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_reprdownMalignant cells

GSE175716

NA
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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."