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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAT2B

Summary for MAT2B

Gene information	Gene symbol	MAT2B
	Ensembl ID	ENSG00000038274
	Entrez ID	27430
	Gene name	methionine adenosyltransferase 2B
	Synonyms	MATIIbeta\|SDR23E1
	Gene type	protein_coding
	UniProtAcc	Q9NZL9

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Dataset with differentially expressed gene: MAT2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.268183	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.302114	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.596334	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.257592	5.20e-40

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Expression of MAT2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAT2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAT2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAT2B	hsa-miR-4795-3p	99.3864	NM_013283
MAT2B	hsa-miR-5003-3p	96.7254	NM_182796
MAT2B	hsa-miR-126-5p	95.9213	NM_013283
MAT2B	hsa-miR-377-3p	95.7121	NM_182796
MAT2B	hsa-miR-548aw	94.8199	NM_013283
MAT2B	hsa-miR-5696	94.4334	NM_182796
MAT2B	hsa-miR-4775	94.2096	NM_182796
MAT2B	hsa-miR-1227-3p	93.868	NM_013283
MAT2B	hsa-miR-6513-3p	93.6877	NM_182796
MAT2B	hsa-miR-6080	91.1316	NM_013283
MAT2B	hsa-miR-548g-5p	90.7495	NM_013283
MAT2B	hsa-miR-548aj-5p	90.7495	NM_013283
MAT2B	hsa-miR-548x-5p	90.7495	NM_013283
MAT2B	hsa-miR-548f-5p	90.7495	NM_013283
MAT2B	hsa-miR-1468-3p	88.5948	NM_013283
MAT2B	hsa-miR-548o-3p	88.5537	NM_013283
MAT2B	hsa-miR-1323	88.5537	NM_013283
MAT2B	hsa-miR-656-3p	88.3882	NM_013283
MAT2B	hsa-miR-514b-5p	87.74	NM_013283
MAT2B	hsa-miR-513c-5p	87.74	NM_013283
MAT2B	hsa-miR-590-3p	86.6616	NM_013283
MAT2B	hsa-miR-5187-5p	86.4768	NM_182796
MAT2B	hsa-miR-372-5p	85.5277	NM_182796
MAT2B	hsa-miR-138-2-3p	84.9797	NM_182796
MAT2B	hsa-miR-190a-3p	84.8369	NM_182796
MAT2B	hsa-miR-4677-5p	84.7184	NM_182796
MAT2B	hsa-miR-1843	84.7138	NM_182796
MAT2B	hsa-miR-4802-5p	84.7138	NM_182796
MAT2B	hsa-miR-452-3p	84.5765	NM_182796
MAT2B	hsa-miR-4729	84.1238	NM_182796
MAT2B	hsa-miR-454-3p	83.0665	NM_013283
MAT2B	hsa-miR-4666a-5p	83.0239	NM_013283
MAT2B	hsa-miR-3064-3p	82.783	NM_013283
MAT2B	hsa-miR-12123	82.2783	NM_182796
MAT2B	hsa-miR-548ax	82.21	NM_182796
MAT2B	hsa-miR-548ao-5p	82.21	NM_182796
MAT2B	hsa-miR-5706	82.1274	NM_182796
MAT2B	hsa-miR-4782-5p	82.1274	NM_182796
MAT2B	hsa-miR-4698	81.6646	NM_182796
MAT2B	hsa-miR-527	81.2271	NM_013283
MAT2B	hsa-miR-518a-5p	81.2271	NM_013283
MAT2B	hsa-miR-5002-3p	80.1573	NM_182796

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Motifs and transcription factors (TFs) regulating MAT2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAT2B	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MAT2B	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MAT2B	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MAT2B	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MAT2B	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MAT2B	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MAT2B	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
MAT2B	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
MAT2B	transfac_pro__M00652	NRF1 (directAnnotation).
MAT2B	metacluster_55.5	ZNF541 (directAnnotation).
MAT2B	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
MAT2B	hdpi__ETV4	ETV4 (directAnnotation).
MAT2B	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
MAT2B	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
MAT2B	transfac_pro__M01298	MECP2 (directAnnotation).
MAT2B	cisbp__M01815	CEBPE (inferredBy_Orthology).
MAT2B	taipale_tf_pairs__FLI1_DLX2_RSCGGAARYAATTA_CAP	DLX2; FLI1 (directAnnotation).
MAT2B	transfac_pro__M06832	PEG3 (directAnnotation).
MAT2B	transfac_pro__M06259	ZNF91 (directAnnotation).
MAT2B	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
MAT2B	transfac_pro__M05805	ZNF546 (directAnnotation).
MAT2B	metacluster_108.2	ZNF286A (directAnnotation).
MAT2B	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
MAT2B	tfdimers__MD00208	IRF1; LTF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."