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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MARK2

Summary for MARK2

Gene information	Gene symbol	MARK2
	Ensembl ID	ENSG00000072518
	Entrez ID	2011
	Gene name	microtubule affinity regulating kinase 2
	Synonyms	EMK1\|PAR-1\|PAR-1B\|Par1b
	Gene type	protein_coding
	UniProtAcc	Q7KZI7

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Dataset with differentially expressed gene: MARK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.250846	4.73e-41

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Expression of MARK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MARK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MARK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MARK2	hsa-miR-486-3p	97.2365	NM_001163296
MARK2	hsa-miR-6721-5p	96.7283	NM_001039469
MARK2	hsa-miR-4753-3p	95.3016	NM_001039469
MARK2	hsa-miR-4763-3p	92.7636	NM_001039469
MARK2	hsa-miR-1207-5p	92.7636	NM_001039469
MARK2	hsa-miR-551b-5p	92.5368	NM_001039469
MARK2	hsa-miR-6722-3p	92.3481	NM_001039469
MARK2	hsa-miR-3175	91.2963	NM_001163296
MARK2	hsa-miR-6827-5p	90.4135	NM_001163296
MARK2	hsa-miR-3613-3p	88.3035	NM_001163296
MARK2	hsa-miR-1909-3p	88.201	NM_001039469
MARK2	hsa-miR-4693-3p	86.6716	NM_001163296
MARK2	hsa-miR-7106-5p	86.5767	NM_001163296
MARK2	hsa-miR-6836-3p	85.6821	NM_001039469
MARK2	hsa-miR-640	85.3776	NM_001039469
MARK2	hsa-miR-4456	84.9331	NM_001039469
MARK2	hsa-miR-539-5p	83.9763	NM_001163296
MARK2	hsa-miR-2861	83.0983	NM_001163296
MARK2	hsa-miR-4725-3p	82.8166	NM_001163296
MARK2	hsa-miR-6780b-5p	82.8166	NM_001163296
MARK2	hsa-miR-3152-5p	82.7568	NM_001039469
MARK2	hsa-miR-4271	82.6561	NM_001163296
MARK2	hsa-miR-4710	81.8479	NM_001163296
MARK2	hsa-miR-6782-5p	80.9226	NM_001163296
MARK2	hsa-miR-1199-5p	80.8655	NM_001163296
MARK2	hsa-miR-3163	80.6863	NM_001163296
MARK2	hsa-miR-6751-3p	80.6662	NM_001163296
MARK2	hsa-miR-6887-3p	80.5326	NM_001039469

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Motifs and transcription factors (TFs) regulating MARK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MARK2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MARK2	jaspar__MA1483.2	ELF2 (directAnnotation).
MARK2	metacluster_151.2	ZNF23 (directAnnotation).
MARK2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MARK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MARK2	hdpi__ETV4	ETV4 (directAnnotation).
MARK2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
MARK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MARK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."