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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAPRE3

Summary for MAPRE3

Gene information	Gene symbol	MAPRE3
	Ensembl ID	ENSG00000084764
	Entrez ID	22924
	Gene name	microtubule associated protein RP/EB family member 3
	Synonyms	EB3\|RP3
	Gene type	protein_coding
	UniProtAcc	Q9UPY8

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Dataset with differentially expressed gene: MAPRE3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.349315	9.29e-07

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Expression of MAPRE3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAPRE3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAPRE3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAPRE3	hsa-miR-548ah-5p	91.9466	NM_001303050
MAPRE3	hsa-miR-3609	91.9466	NM_001303050
MAPRE3	hsa-miR-106b-5p	91.5043	NM_001303050
MAPRE3	hsa-miR-20a-5p	91.5043	NM_001303050
MAPRE3	hsa-miR-20b-5p	91.0919	NM_001303050
MAPRE3	hsa-miR-519d-3p	91.0919	NM_001303050
MAPRE3	hsa-miR-526b-3p	91.0919	NM_001303050
MAPRE3	hsa-miR-17-5p	91.0919	NM_001303050
MAPRE3	hsa-miR-106a-5p	91.0919	NM_001303050
MAPRE3	hsa-miR-93-5p	91.0919	NM_001303050
MAPRE3	hsa-miR-4292	87.7912	NM_001303050
MAPRE3	hsa-miR-6791-5p	87.7912	NM_001303050
MAPRE3	hsa-miR-6124	84.7984	NM_001303050
MAPRE3	hsa-miR-6875-5p	81.7988	NM_001303050
MAPRE3	hsa-miR-3126-5p	81.7988	NM_001303050
MAPRE3	hsa-miR-3692-5p	81.5372	NM_001303050

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Motifs and transcription factors (TFs) regulating MAPRE3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAPRE3	metacluster_136.2	RFX1; RFX2; RFX2; RFX3; RFX3; RFX4; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX7; RFX7; RFXANK; RFXAP (directAnnotation). RFX3; RFX3; RFX4 (inferredBy_Orthology).
MAPRE3	transfac_pro__M06271	ZNF284 (directAnnotation).
MAPRE3	jaspar__MA1724.1	RFX6 (inferredBy_Orthology).
MAPRE3	tfdimers__MD00047	NR3C1; PGR; ZFP42 (directAnnotation).
MAPRE3	transfac_pro__M06292	ZNF766 (directAnnotation).
MAPRE3	tfdimers__MD00032	GFI1; GFI1B; NKX3-2 (directAnnotation).
MAPRE3	transfac_pro__M06241	ZNF345 (directAnnotation).
MAPRE3	tfdimers__MD00557	MZF1 (directAnnotation).
MAPRE3	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
MAPRE3	metacluster_136.3	MAX; MXI1; MXI1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX4; RFX5; RFX5; RFX5; SREBF1; ZBTB7B (directAnnotation). RFX1; RFX1; RFX1; RFX1; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX2; RFX3; RFX3; RFX3; RFX3; RFX3; RFX4; RFX4; RFX4; RFX6; RFX6; RFX6; RFX7; RFX8; RFX8 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."