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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAPRE2

Summary for MAPRE2

Gene information	Gene symbol	MAPRE2
	Ensembl ID	ENSG00000166974
	Entrez ID	10982
	Gene name	microtubule associated protein RP/EB family member 2
	Synonyms	EB1\|EB2\|RP1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MAPRE2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.342203	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.259103	2.03e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.279798	2.54e-29

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Expression of MAPRE2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAPRE2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAPRE2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAPRE2	hsa-miR-4495	98.0827	NM_001143826
MAPRE2	hsa-miR-4446-5p	96.1118	NM_001143826
MAPRE2	hsa-miR-4755-5p	95.642	NM_001143826
MAPRE2	hsa-miR-5006-3p	95.642	NM_001143826
MAPRE2	hsa-miR-4319	94.8797	NM_001143826
MAPRE2	hsa-miR-125b-5p	94.3771	NM_001143826
MAPRE2	hsa-miR-125a-5p	94.3771	NM_001143826
MAPRE2	hsa-miR-4733-3p	94.3758	NM_001143826
MAPRE2	hsa-miR-1299	94.2323	NM_001143826
MAPRE2	hsa-miR-212-5p	94.0404	NM_001143826
MAPRE2	hsa-miR-7973	90.844	NM_001143826
MAPRE2	hsa-miR-5680	90.3431	NM_001143826
MAPRE2	hsa-miR-211-5p	88.534	NM_001143826
MAPRE2	hsa-miR-204-5p	88.534	NM_001143826
MAPRE2	hsa-miR-3662	87.6662	NM_001143826
MAPRE2	hsa-miR-1227-5p	87.3335	NM_001143826
MAPRE2	hsa-miR-942-5p	87.2296	NM_001143826
MAPRE2	hsa-miR-135b-5p	86.7346	NM_001143826
MAPRE2	hsa-miR-135a-5p	86.7346	NM_001143826
MAPRE2	hsa-miR-29c-3p	85.7859	NM_001143826
MAPRE2	hsa-miR-29b-3p	85.7859	NM_001143826
MAPRE2	hsa-miR-29a-3p	85.7859	NM_001143826
MAPRE2	hsa-miR-3646	85.4681	NM_001143826
MAPRE2	hsa-miR-4760-3p	85.0673	NM_001143826
MAPRE2	hsa-miR-1273c	84.8623	NM_001143826
MAPRE2	hsa-miR-6808-3p	84.6772	NM_001143826
MAPRE2	hsa-miR-3119	84.4699	NM_001143826
MAPRE2	hsa-miR-3059-5p	84.2759	NM_001143826
MAPRE2	hsa-miR-548f-5p	83.9138	NM_001143826
MAPRE2	hsa-miR-548g-5p	83.9138	NM_001143826
MAPRE2	hsa-miR-548x-5p	83.9138	NM_001143826
MAPRE2	hsa-miR-548aj-5p	83.9138	NM_001143826
MAPRE2	hsa-miR-498-3p	83.8916	NM_001143826
MAPRE2	hsa-miR-6769a-5p	83.5767	NM_001143826
MAPRE2	hsa-miR-6769b-5p	83.5767	NM_001143826
MAPRE2	hsa-miR-3615	83.4772	NM_001143826
MAPRE2	hsa-miR-504-5p	81.6563	NM_001143826
MAPRE2	hsa-miR-4725-5p	81.6563	NM_001143826
MAPRE2	hsa-miR-6733-5p	80.8358	NM_001143826
MAPRE2	hsa-miR-6739-5p	80.8358	NM_001143826

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Motifs and transcription factors (TFs) regulating MAPRE2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAPRE2	metacluster_23.5	WT1 (directAnnotation).
MAPRE2	transfac_pro__M06092	ZNF28 (directAnnotation).
MAPRE2	transfac_pro__M06592	ZNF486 (directAnnotation).
MAPRE2	tfdimers__MD00129	CRX; NKX3-2 (directAnnotation).
MAPRE2	tfdimers__MD00165	CRX; FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND (directAnnotation).
MAPRE2	cisbp__M00767	ZSCAN10 (inferredBy_Orthology).
MAPRE2	transfac_pro__M06723	ZNF492 (directAnnotation).
MAPRE2	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
MAPRE2	metacluster_155.19	MTF1; MTF1 (directAnnotation).
MAPRE2	transfac_pro__M06251	ZSCAN2 (inferredBy_Orthology).
MAPRE2	metacluster_198.3	ZFP64 (directAnnotation).
MAPRE2	cisbp__M00968	MTF2 (directAnnotation).
MAPRE2	transfac_pro__M00716	ZBTB14 (directAnnotation).
MAPRE2	transfac_pro__M04893	TAF1 (directAnnotation).
MAPRE2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
MAPRE2	transfac_pro__M04916	TAF1 (directAnnotation).
MAPRE2	transfac_pro__M02089	E2F3 (directAnnotation).
MAPRE2	transfac_pro__M07310	SP5 (directAnnotation).
MAPRE2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
MAPRE2	hdpi__NRL	NRL (directAnnotation).
MAPRE2	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MAPRE2	transfac_pro__M07387	ZBTB7A (directAnnotation).
MAPRE2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MAPRE2	transfac_pro__M01783	SP2 (directAnnotation).
MAPRE2	cisbp__M07938	E2F1 (directAnnotation).
MAPRE2	tfdimers__MD00483	ZBTB14 (directAnnotation).
MAPRE2	hdpi__GTF3C2	GTF3C2 (directAnnotation).
MAPRE2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MAPRE2	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
MAPRE2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
MAPRE2	transfac_pro__M03806	ZBTB7C (directAnnotation).
MAPRE2	hdpi__ZNF304	ZNF304 (directAnnotation).
MAPRE2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MAPRE2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MAPRE2	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MAPRE2	cisbp__M00343	PAX6 (directAnnotation).
MAPRE2	transfac_pro__M12697	ZNF142 (directAnnotation).
MAPRE2	transfac_pro__M00938	E2F1 (directAnnotation).
MAPRE2	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
MAPRE2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MAPRE2	transfac_pro__M12694	ZFP14 (directAnnotation).
MAPRE2	transfac_pro__M04617	ZBTB7A (directAnnotation).
MAPRE2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MAPRE2	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
MAPRE2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MAPRE2	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
MAPRE2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
MAPRE2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MAPRE2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MAPRE2	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."