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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAPRE1

Summary for MAPRE1

Gene information	Gene symbol	MAPRE1
	Ensembl ID	ENSG00000101367
	Entrez ID	22919
	Gene name	microtubule associated protein RP/EB family member 1
	Synonyms	EB1
	Gene type	protein_coding
	UniProtAcc	Q15691

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Dataset with differentially expressed gene: MAPRE1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.611792	8.99e-06
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.46003	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.359944	9.43e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.289313	9.43e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.339156	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.303979	2.02e-12
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.262492	0.00e+00

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Expression of MAPRE1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAPRE1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAPRE1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAPRE1	hsa-miR-519e-5p	98.6703	NM_012325
MAPRE1	hsa-miR-515-5p	98.6703	NM_012325
MAPRE1	hsa-miR-4717-5p	97.8548	NM_012325
MAPRE1	hsa-miR-339-5p	96.7293	NM_012325
MAPRE1	hsa-miR-3194-3p	95.8854	NM_012325
MAPRE1	hsa-miR-371a-5p	95.3359	NM_012325
MAPRE1	hsa-miR-6805-3p	95.2657	NM_012325
MAPRE1	hsa-miR-5691	95.2657	NM_012325
MAPRE1	hsa-miR-6885-3p	94.9418	NM_012325
MAPRE1	hsa-miR-6768-3p	94.4857	NM_012325
MAPRE1	hsa-miR-5589-3p	94.0457	NM_012325
MAPRE1	hsa-miR-519d-5p	94.0356	NM_012325
MAPRE1	hsa-miR-6133	94.0168	NM_012325
MAPRE1	hsa-miR-6127	94.0168	NM_012325
MAPRE1	hsa-miR-4510	94.0168	NM_012325
MAPRE1	hsa-miR-6129	94.0168	NM_012325
MAPRE1	hsa-miR-6130	94.0168	NM_012325
MAPRE1	hsa-miR-4753-5p	93.4469	NM_012325
MAPRE1	hsa-miR-1256	92.5415	NM_012325
MAPRE1	hsa-miR-9983-3p	92.4671	NM_012325
MAPRE1	hsa-miR-5579-3p	92.2824	NM_012325
MAPRE1	hsa-miR-29a-3p	90.7957	NM_012325
MAPRE1	hsa-miR-29c-3p	90.7957	NM_012325
MAPRE1	hsa-miR-29b-3p	90.7957	NM_012325
MAPRE1	hsa-miR-129-5p	90.0695	NM_012325
MAPRE1	hsa-miR-23b-5p	90.0593	NM_012325
MAPRE1	hsa-miR-10b-5p	89.2203	NM_012325
MAPRE1	hsa-miR-10a-5p	89.2203	NM_012325
MAPRE1	hsa-miR-23a-5p	89.0992	NM_012325
MAPRE1	hsa-miR-6732-3p	88.7444	NM_012325
MAPRE1	hsa-miR-4797-3p	88.67	NM_012325
MAPRE1	hsa-miR-766-3p	88.5777	NM_012325
MAPRE1	hsa-miR-6828-5p	87.877	NM_012325
MAPRE1	hsa-miR-369-3p	87.5132	NM_012325
MAPRE1	hsa-miR-3941	87.4062	NM_012325
MAPRE1	hsa-miR-1266-5p	87.327	NM_012325
MAPRE1	hsa-miR-4518	87.327	NM_012325
MAPRE1	hsa-miR-429	87.2982	NM_012325
MAPRE1	hsa-miR-200b-3p	87.2982	NM_012325
MAPRE1	hsa-miR-200c-3p	87.2982	NM_012325
MAPRE1	hsa-miR-582-5p	87.2298	NM_012325
MAPRE1	hsa-miR-23a-3p	87.0753	NM_012325
MAPRE1	hsa-miR-23c	87.0753	NM_012325
MAPRE1	hsa-miR-23b-3p	87.0753	NM_012325
MAPRE1	hsa-miR-3910	86.7298	NM_012325
MAPRE1	hsa-miR-3059-5p	86.5799	NM_012325
MAPRE1	hsa-miR-519a-3p	86.4611	NM_012325
MAPRE1	hsa-miR-519b-3p	86.4611	NM_012325
MAPRE1	hsa-miR-519c-3p	86.4611	NM_012325
MAPRE1	hsa-miR-548as-3p	85.4523	NM_012325

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Motifs and transcription factors (TFs) regulating MAPRE1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAPRE1	transfac_pro__M06140	ZNF250 (directAnnotation).
MAPRE1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MAPRE1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MAPRE1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MAPRE1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MAPRE1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MAPRE1	metacluster_3.14	WT1; WT1 (directAnnotation).
MAPRE1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MAPRE1	cisbp__M07938	E2F1 (directAnnotation).
MAPRE1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
MAPRE1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
MAPRE1	transfac_pro__M04617	ZBTB7A (directAnnotation).
MAPRE1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
MAPRE1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MAPRE1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
MAPRE1	transfac_pro__M07387	ZBTB7A (directAnnotation).
MAPRE1	transfac_pro__M07436	WT1 (directAnnotation).
MAPRE1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
MAPRE1	transfac_pro__M00716	ZBTB14 (directAnnotation).
MAPRE1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MAPRE1	hdpi__HIP2	UBE2K (directAnnotation).
MAPRE1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MAPRE1	transfac_pro__M04893	TAF1 (directAnnotation).
MAPRE1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MAPRE1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
MAPRE1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MAPRE1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MAPRE1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
MAPRE1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
MAPRE1	transfac_pro__M01783	SP2 (directAnnotation).
MAPRE1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MAPRE1	transfac_pro__M01253	CNOT3 (directAnnotation).
MAPRE1	metacluster_7.13	ZFX (directAnnotation).
MAPRE1	cisbp__M00968	MTF2 (directAnnotation).
MAPRE1	transfac_pro__M04817	ZBTB33 (directAnnotation).
MAPRE1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
MAPRE1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MAPRE1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
MAPRE1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
MAPRE1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MAPRE1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
MAPRE1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MAPRE1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
MAPRE1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MAPRE1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
MAPRE1	jaspar__MA1933.1	SREBF2 (directAnnotation).
MAPRE1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
MAPRE1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
MAPRE1	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
MAPRE1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."