Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Neutrophils | 0.329861 | 1.61e-03 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | -0.278811 | 0.00e+00 |
GSE168668 | LNCaP cell line | Cell line | Prostate cancer | Prostate cancer | Targeted therapy | enzalutamide | NA | Malignant cells | 0.499678 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | -0.539389 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | -0.350762 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | -0.273726 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | Malignant cells | -0.305294 | 0.00e+00 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | post | Malignant cells | 0.261919 | 0.00e+00 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | pre | Malignant cells | 0.505068 | 0.00e+00 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | 0.634454 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
MAPKAPK2 | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
MAPKAPK2 | metacluster_197.2 | E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT | ELK1; HOXA1 (directAnnotation). |
MAPKAPK2 | transfac_pro__M06660 | ZNF670 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__ELK1_PAX5_RSCGGAACYACGCWYSANTG_CAP_repr | ELK1; PAX5 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP | ETV4; GCM1 (directAnnotation). |
MAPKAPK2 | transfac_pro__M04722 | SPI1 (directAnnotation). |
MAPKAPK2 | tfdimers__MD00145 | ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation). |
MAPKAPK2 | metacluster_7.13 | ZFX (directAnnotation). |
MAPKAPK2 | dbtfbs__ZNF407_representative_N1 | ZNF407 (directAnnotation). |
MAPKAPK2 | cisbp__M00968 | MTF2 (directAnnotation). |
MAPKAPK2 | kznf__ZNF730_Imbeault2017_RP_RCADE | ZNF730 (directAnnotation). |
MAPKAPK2 | transfac_pro__M07310 | SP5 (directAnnotation). |
MAPKAPK2 | kznf__ZNF571_Imbeault2017_OM_RCADE | ZNF571 (directAnnotation). |
MAPKAPK2 | metacluster_144.8 | ZNF30; ZNF30 (directAnnotation). |
MAPKAPK2 | metacluster_144.3 | ZNF704; ZNF704 (directAnnotation). |
MAPKAPK2 | metacluster_151.2 | ZNF23 (directAnnotation). |
MAPKAPK2 | kznf__ZNF548_Imbeault2017_RP_RCADE | ZNF548 (directAnnotation). |
MAPKAPK2 | metacluster_133.1 | ZNF304; ZNF304; ZSCAN22 (directAnnotation). |
MAPKAPK2 | dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1 | ZSCAN30 (directAnnotation). |
MAPKAPK2 | transfac_pro__M01253 | CNOT3 (directAnnotation). |
MAPKAPK2 | metacluster_144.5 | ZNF610; ZNF610; ZNF610 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr | E2F8; TFAP2C (directAnnotation). |
MAPKAPK2 | kznf__ZNF783_Imbeault2017_OM_MEME | ZNF783 (directAnnotation). |
MAPKAPK2 | kznf__ZNF90_Imbeault2017_OM_RCADE | ZNF90 (directAnnotation). |
MAPKAPK2 | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
MAPKAPK2 | jaspar__MA0535.1 | SMAD9 (inferredBy_Orthology). |
MAPKAPK2 | transfac_pro__M04817 | ZBTB33 (directAnnotation). |
MAPKAPK2 | transfac_pro__M12697 | ZNF142 (directAnnotation). |
MAPKAPK2 | transfac_pro__M01973 | PLAG1 (directAnnotation). |
MAPKAPK2 | tfdimers__MD00483 | ZBTB14 (directAnnotation). |
MAPKAPK2 | metacluster_198.3 | ZFP64 (directAnnotation). |
MAPKAPK2 | transfac_pro__M01303 | SP1 (directAnnotation). |
MAPKAPK2 | kznf__ZNF383_Imbeault2017_RP_RCADE | ZNF383 (directAnnotation). |
MAPKAPK2 | transfac_public__M00189 | TFAP2A; TFAP2B; TFAP2C (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr | HES7; TFAP2C (directAnnotation). |
MAPKAPK2 | transfac_pro__M01199 | TRIM28 (directAnnotation). |
MAPKAPK2 | transfac_pro__M01122 | ZNF219 (directAnnotation). |
MAPKAPK2 | homer__GGGGGGGG_Maz | MAZ (directAnnotation). |
MAPKAPK2 | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
MAPKAPK2 | cisbp__M00341 | PAX6 (directAnnotation). |
MAPKAPK2 | tfdimers__MD00151 | CHURC1 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr | HOXB2; PAX1 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__HOXB2_PAX9_NNMATTAGTCACGCWTSRNTG_CAP | HOXB2; PAX9 (directAnnotation). |
MAPKAPK2 | jaspar__MA1684.1 | FOXN1 (inferredBy_Orthology). |
MAPKAPK2 | metacluster_155.36 | ZNF729 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP | HOXA2; TEAD4 (directAnnotation). |
MAPKAPK2 | transfac_pro__M06484 | ZNF683 (directAnnotation). |
MAPKAPK2 | taipale_tf_pairs__GCM1_FOXI1_NNGTMAATANGGGYR_CAP | FOXI1; GCM1 (directAnnotation). |
MAPKAPK2 | transfac_pro__M06071 | ZNF814 (directAnnotation). |
Target name | Drug name | Drug ID | Drug type |
MAPKAPK2 | "(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3 | DB07430 | small molecule |
MAPKAPK2 | "(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one" | DB07431 | small molecule |
MAPKAPK2 | "(4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAH | DB07406 | small molecule |
MAPKAPK2 | "2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE" | DB08358 | small molecule |
MAPKAPK2 | "2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE" | DB07728 | small molecule |
MAPKAPK2 | "3-{[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione" | DB07234 | small molecule |
MAPKAPK2 | "Staurosporine" | DB02010 | small molecule |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |