Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP7D3

Summary for MAP7D3

Gene information	Gene symbol	MAP7D3
	Ensembl ID	ENSG00000129680
	Entrez ID	79649
	Gene name	MAP7 domain containing 3
	Synonyms	FLJ12649
	Gene type	protein_coding
	UniProtAcc	Q8IWC1

Top

Dataset with differentially expressed gene: MAP7D3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.531631	6.95e-39
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.367417	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.48677	1.99e-43
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.533442	3.67e-32
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.406206	9.76e-22
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.708366	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.47804	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.400103	0.00e+00

Top

Expression of MAP7D3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MAP7D3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MAP7D3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP7D3	hsa-miR-4469	94.0115	NM_001173517
MAP7D3	hsa-miR-4267	92.3519	NM_001173517
MAP7D3	hsa-miR-4801	91.992	NM_001173516
MAP7D3	hsa-miR-4731-3p	91.7345	NM_001173516
MAP7D3	hsa-miR-26a-1-3p	91.5353	NM_001173516
MAP7D3	hsa-miR-26a-2-3p	91.5353	NM_001173516
MAP7D3	hsa-miR-4768-3p	89.116	NM_001173517
MAP7D3	hsa-miR-877-5p	88.563	NM_001173516
MAP7D3	hsa-miR-34a-5p	86.7954	NM_001173517
MAP7D3	hsa-miR-449a	86.7954	NM_001173517
MAP7D3	hsa-miR-607	85.8094	NM_001173516
MAP7D3	hsa-miR-3123	85.355	NM_001173516
MAP7D3	hsa-miR-3200-3p	84.8607	NM_001173517
MAP7D3	hsa-miR-3613-3p	83.6468	NM_001173516
MAP7D3	hsa-miR-6778-5p	83.4576	NM_001173517
MAP7D3	hsa-miR-1233-5p	83.4576	NM_001173517
MAP7D3	hsa-miR-32-5p	82.8389	NM_001173517
MAP7D3	hsa-miR-92b-3p	82.8389	NM_001173517
MAP7D3	hsa-miR-92a-3p	82.8389	NM_001173517
MAP7D3	hsa-miR-34c-5p	82.1338	NM_001173517
MAP7D3	hsa-miR-449b-5p	82.1338	NM_001173517
MAP7D3	hsa-miR-4766-5p	81.6392	NM_001173516
MAP7D3	hsa-miR-616-5p	81.0493	NM_001173516
MAP7D3	hsa-miR-373-5p	81.0493	NM_001173516
MAP7D3	hsa-miR-371b-5p	81.0493	NM_001173516
MAP7D3	hsa-miR-4689	81.035	NM_001173516
MAP7D3	hsa-miR-593-3p	80.9542	NM_001173516
MAP7D3	hsa-miR-6818-3p	80.2636	NM_001173516

Page: 1

Top

Motifs and transcription factors (TFs) regulating MAP7D3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP7D3	metacluster_151.2	ZNF23 (directAnnotation).
MAP7D3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MAP7D3	transfac_pro__M05479	ZNF580 (directAnnotation).
MAP7D3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MAP7D3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAP7D3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MAP7D3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MAP7D3	jaspar__MA0079.5	SP1 (directAnnotation).
MAP7D3	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
MAP7D3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MAP7D3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MAP7D3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MAP7D3	transfac_pro__M00652	NRF1 (directAnnotation).
MAP7D3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MAP7D3	transfac_pro__M04866	HDAC2 (directAnnotation).
MAP7D3	jaspar__MA1122.1	TFDP1 (directAnnotation).
MAP7D3	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
MAP7D3	transfac_pro__M04794	TAF1 (directAnnotation).
MAP7D3	jaspar__MA0748.2	YY2 (directAnnotation).
MAP7D3	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
MAP7D3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
MAP7D3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MAP7D3	swissregulon__hs__ETV6	ETV6 (directAnnotation).
MAP7D3	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
MAP7D3	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."