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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP3K7CL

Summary for MAP3K7CL

Gene information	Gene symbol	MAP3K7CL
	Ensembl ID	ENSG00000156265
	Entrez ID	56911
	Gene name	MAP3K7 C-terminal like
	Synonyms	C21orf7\|TAK1L\|TAKL\|TAKL-1\|TAKL-2\|TAKL-4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MAP3K7CL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	-0.450252	6.48e-17

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Expression of MAP3K7CL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP3K7CL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAP3K7CL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP3K7CL	hsa-miR-551b-5p	96.2514	NM_001286623
MAP3K7CL	hsa-miR-5696	95.3333	NM_001286617
MAP3K7CL	hsa-miR-548c-3p	95.3176	NM_001286620
MAP3K7CL	hsa-miR-4695-3p	94.6937	NM_001286617
MAP3K7CL	hsa-miR-141-5p	93.8702	NM_001286617
MAP3K7CL	hsa-miR-342-3p	93.5039	NM_001286623
MAP3K7CL	hsa-miR-6831-5p	92.795	NM_001286620
MAP3K7CL	hsa-miR-3128	92.6404	NM_001286620
MAP3K7CL	hsa-miR-4716-5p	89.9624	NM_001286620
MAP3K7CL	hsa-miR-5093	89.696	NM_001286623
MAP3K7CL	hsa-miR-3923	89.2479	NM_001286620
MAP3K7CL	hsa-miR-4646-3p	88.855	NM_001286620
MAP3K7CL	hsa-miR-6131	86.5062	NM_001286623
MAP3K7CL	hsa-miR-568	85.5814	NM_001286623
MAP3K7CL	hsa-miR-3927-3p	85.1625	NM_001286620
MAP3K7CL	hsa-miR-143-5p	85.0131	NM_001286623
MAP3K7CL	hsa-miR-8054	83.941	NM_001286623
MAP3K7CL	hsa-miR-548k	83.941	NM_001286623
MAP3K7CL	hsa-miR-548av-5p	83.941	NM_001286623
MAP3K7CL	hsa-miR-4526	81.4719	NM_001286620
MAP3K7CL	hsa-miR-3660	81.4719	NM_001286620
MAP3K7CL	hsa-miR-5087	81.1135	NM_001286623
MAP3K7CL	hsa-miR-3941	80.3122	NM_001286623

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Motifs and transcription factors (TFs) regulating MAP3K7CL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP3K7CL	taipale_cyt_meth__ZNF396_NTGTMCRAAAN_FL_meth_repr	ZNF396 (directAnnotation).
MAP3K7CL	taipale_cyt_meth__NKX2-3_NTCGTTGAN_eDBD_meth	NKX2-3 (directAnnotation).
MAP3K7CL	metacluster_79.1	ZNF713; ZNF713; ZNF713 (directAnnotation).
MAP3K7CL	transfac_pro__M06647	ZNF665 (directAnnotation).
MAP3K7CL	kznf__ZNF302_Imbeault2017_RP_RCADE	ZNF302 (directAnnotation).
MAP3K7CL	transfac_pro__M05357	POU4F2 (directAnnotation).
MAP3K7CL	transfac_pro__M06338	ZNF813 (directAnnotation).
MAP3K7CL	kznf__ZNF605_Imbeault2017_OM_RCADE	ZNF605 (directAnnotation).
MAP3K7CL	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
MAP3K7CL	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
MAP3K7CL	transfac_pro__M06513	ZFP90 (directAnnotation).
MAP3K7CL	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
MAP3K7CL	transfac_pro__M06267	ZNF805 (directAnnotation).
MAP3K7CL	taipale_tf_pairs__GCM1_HOXA2_RTRSGGGNNTAATKR_CAP_repr	GCM1; HOXA2 (directAnnotation).
MAP3K7CL	metacluster_122.17	IRF6 (directAnnotation).
MAP3K7CL	taipale_tf_pairs__ETV2_FOXI1_RSCGGAANNRYMAACAN_CAP	ETV2; FOXI1 (directAnnotation).
MAP3K7CL	taipale_tf_pairs__HOXB2_ELF1_NNYMATTANNNNNNNGGAAGNN_CAP_repr	ELF1; HOXB2 (directAnnotation).
MAP3K7CL	transfac_pro__M01694	YY2 (directAnnotation). MBTPS2 (inferredBy_Orthology).
MAP3K7CL	metacluster_172.22	E4F1 (inferredBy_Orthology).
MAP3K7CL	tfdimers__MD00218	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM; ELF1 (directAnnotation).
MAP3K7CL	transfac_pro__M06432	ZNF571 (directAnnotation).
MAP3K7CL	transfac_pro__M05519	FEZF2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."