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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAP3K5

Summary for MAP3K5

Gene information	Gene symbol	MAP3K5
	Ensembl ID	ENSG00000197442
	Entrez ID	4217
	Gene name	mitogen-activated protein kinase kinase kinase 5
	Synonyms	ASK1\|MAPKKK5\|MEKK5
	Gene type	protein_coding
	UniProtAcc	Q99683

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Dataset with differentially expressed gene: MAP3K5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.304354	8.99e-11

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Expression of MAP3K5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP3K5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MAP3K5	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating MAP3K5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP3K5	hsa-miR-4775	99.4881	NM_005923
MAP3K5	hsa-miR-1243	95.7997	NM_005923
MAP3K5	hsa-miR-548c-3p	95.0669	NM_005923
MAP3K5	hsa-miR-3129-5p	95.0192	NM_005923
MAP3K5	hsa-miR-199b-3p	95.0192	NM_005923
MAP3K5	hsa-miR-199a-3p	95.0192	NM_005923
MAP3K5	hsa-miR-425-5p	94.5955	NM_005923
MAP3K5	hsa-miR-8064	92.5936	NM_005923
MAP3K5	hsa-miR-30b-5p	90.79	NM_005923
MAP3K5	hsa-miR-30e-5p	90.79	NM_005923
MAP3K5	hsa-miR-30d-5p	90.79	NM_005923
MAP3K5	hsa-miR-30c-5p	90.79	NM_005923
MAP3K5	hsa-miR-30a-5p	90.79	NM_005923
MAP3K5	hsa-let-7f-2-3p	90.7715	NM_005923
MAP3K5	hsa-miR-1185-2-3p	90.7715	NM_005923
MAP3K5	hsa-miR-1185-1-3p	90.7715	NM_005923
MAP3K5	hsa-miR-181a-3p	90.5335	NM_005923
MAP3K5	hsa-miR-524-5p	90.4577	NM_005923
MAP3K5	hsa-miR-520d-5p	90.4577	NM_005923
MAP3K5	hsa-miR-587	89.5827	NM_005923
MAP3K5	hsa-miR-936	89.3185	NM_005923
MAP3K5	hsa-miR-23b-3p	88.905	NM_005923
MAP3K5	hsa-miR-23c	88.905	NM_005923
MAP3K5	hsa-miR-23a-3p	88.905	NM_005923
MAP3K5	hsa-miR-4302	88.5757	NM_005923
MAP3K5	hsa-miR-5587-5p	88.5051	NM_005923
MAP3K5	hsa-miR-4753-3p	88.496	NM_005923
MAP3K5	hsa-miR-4742-3p	85.9635	NM_005923
MAP3K5	hsa-miR-222-5p	85.0202	NM_005923
MAP3K5	hsa-miR-582-3p	84.2096	NM_005923
MAP3K5	hsa-miR-7-1-3p	83.8641	NM_005923
MAP3K5	hsa-miR-7-2-3p	83.8641	NM_005923
MAP3K5	hsa-miR-371a-5p	81.9458	NM_005923
MAP3K5	hsa-miR-12124	81.7509	NM_005923
MAP3K5	hsa-miR-548ac	80.8302	NM_005923
MAP3K5	hsa-miR-548d-3p	80.8302	NM_005923
MAP3K5	hsa-miR-548h-3p	80.8302	NM_005923
MAP3K5	hsa-miR-548bb-3p	80.8302	NM_005923
MAP3K5	hsa-miR-548z	80.8302	NM_005923
MAP3K5	hsa-miR-216b-3p	80.0775	NM_005923

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Motifs and transcription factors (TFs) regulating MAP3K5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP3K5	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
MAP3K5	transfac_pro__M04918	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."