Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MAP3K10

Summary for MAP3K10

Gene information	Gene symbol	MAP3K10
	Ensembl ID	ENSG00000130758
	Entrez ID	4294
	Gene name	mitogen-activated protein kinase kinase kinase 10
	Synonyms	MEKK10\|MLK2\|MST
	Gene type	protein_coding
	UniProtAcc	Q02779

Top

Dataset with differentially expressed gene: MAP3K10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.251659	1.80e-18

Top

Expression of MAP3K10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MAP3K10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MAP3K10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP3K10	hsa-miR-6793-3p	95.7002	NM_002446
MAP3K10	hsa-miR-4319	88.4976	NM_002446
MAP3K10	hsa-miR-2355-5p	85.3305	NM_002446
MAP3K10	hsa-miR-125a-5p	85.1514	NM_002446
MAP3K10	hsa-miR-125b-5p	85.1514	NM_002446
MAP3K10	hsa-miR-155-5p	82.3607	NM_002446
MAP3K10	hsa-miR-3121-3p	81.2938	NM_002446
MAP3K10	hsa-miR-95-5p	80.4424	NM_002446
MAP3K10	hsa-miR-5586-3p	80.2436	NM_002446

Page: 1

Top

Motifs and transcription factors (TFs) regulating MAP3K10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP3K10	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MAP3K10	metacluster_7.13	ZFX (directAnnotation).
MAP3K10	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAP3K10	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
MAP3K10	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MAP3K10	"Fostamatinib"	DB12010	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."