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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MAP2

Summary for MAP2

Gene information	Gene symbol	MAP2
	Ensembl ID	ENSG00000078018
	Entrez ID	4133
	Gene name	microtubule associated protein 2
	Synonyms	MAP2A\|MAP2B\|MAP2C
	Gene type	protein_coding
	UniProtAcc	P11137

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Dataset with differentially expressed gene: MAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.536556	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.686274	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.389422	0.00e+00

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Expression of MAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAP2	hsa-miR-6867-5p	99.9989	NM_001039538
MAP2	hsa-miR-200c-3p	99.5898	NM_001039538
MAP2	hsa-miR-429	99.5898	NM_001039538
MAP2	hsa-miR-200b-3p	99.5898	NM_001039538
MAP2	hsa-miR-3133	99.2773	NM_031847
MAP2	hsa-miR-5011-5p	99.1149	NM_031847
MAP2	hsa-miR-3148	99.1017	NM_031847
MAP2	hsa-miR-3074-5p	98.8223	NM_001039538
MAP2	hsa-miR-5692a	98.7328	NM_001039538
MAP2	hsa-miR-186-5p	98.6614	NM_031847
MAP2	hsa-miR-450b-5p	98.325	NM_031847
MAP2	hsa-miR-548aw	97.94	NM_001039538
MAP2	hsa-miR-664a-3p	97.7621	NM_031847
MAP2	hsa-miR-3688-3p	97.3622	NM_001039538
MAP2	hsa-miR-190a-3p	97.3419	NM_031847
MAP2	hsa-miR-6875-3p	96.7393	NM_031847
MAP2	hsa-miR-3163	96.3931	NM_001039538
MAP2	hsa-miR-548c-3p	95.8153	NM_001039538
MAP2	hsa-miR-3121-3p	95.5956	NM_031847
MAP2	hsa-miR-34b-3p	95.5059	NM_031847
MAP2	hsa-miR-369-3p	95.498	NM_001039538
MAP2	hsa-miR-4738-3p	95.3855	NM_001039538
MAP2	hsa-miR-4797-5p	95.1744	NM_001039538
MAP2	hsa-miR-6715b-5p	94.1246	NM_001039538
MAP2	hsa-miR-4269	94.1246	NM_001039538
MAP2	hsa-miR-3155a	93.8853	NM_001039538
MAP2	hsa-miR-484	93.8853	NM_001039538
MAP2	hsa-miR-3155b	93.8853	NM_001039538
MAP2	hsa-miR-4693-5p	93.7888	NM_001039538
MAP2	hsa-miR-361-5p	93.5412	NM_031847
MAP2	hsa-miR-7977	92.6661	NM_001039538
MAP2	hsa-miR-4282	92.3218	NM_031847
MAP2	hsa-miR-4684-3p	92.0201	NM_031847
MAP2	hsa-miR-5589-3p	91.7946	NM_001039538
MAP2	hsa-miR-1301-5p	91.4484	NM_001039538
MAP2	hsa-miR-6502-5p	91.4484	NM_001039538
MAP2	hsa-miR-8084	91.443	NM_001039538
MAP2	hsa-miR-4714-5p	91.0507	NM_001039538
MAP2	hsa-miR-153-5p	91.0229	NM_031847
MAP2	hsa-miR-1252-3p	90.7259	NM_001039538
MAP2	hsa-miR-1297	90.673	NM_001039538
MAP2	hsa-miR-5582-3p	90.589	NM_001039538
MAP2	hsa-miR-3120-3p	90.1234	NM_031847
MAP2	hsa-miR-6730-5p	90.055	NM_031847
MAP2	hsa-miR-1185-1-3p	89.719	NM_001039538
MAP2	hsa-miR-1185-2-3p	89.719	NM_001039538
MAP2	hsa-let-7f-2-3p	89.2745	NM_001039538
MAP2	hsa-miR-539-5p	89.0687	NM_031847
MAP2	hsa-miR-4438	88.7609	NM_001039538
MAP2	hsa-miR-6501-3p	88.6826	NM_031847

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Motifs and transcription factors (TFs) regulating MAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
MAP2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
MAP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
MAP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MAP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MAP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
MAP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MAP2	transfac_pro__M00652	NRF1 (directAnnotation).
MAP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MAP2	transfac_pro__M04866	HDAC2 (directAnnotation).
MAP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
MAP2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
MAP2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
MAP2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MAP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MAP2	metacluster_7.13	ZFX (directAnnotation).
MAP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MAP2	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
MAP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MAP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MAP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MAP2	cisbp__M00249	WT1 (directAnnotation).
MAP2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
MAP2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MAP2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MAP2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MAP2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MAP2	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
MAP2	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MAP2	"Docetaxel"	DB01248	small molecule
MAP2	"Estramustine"	DB01196	small molecule
MAP2	"Paclitaxel"	DB01229	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."