Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MAOA

Summary for MAOA

Gene information	Gene symbol	MAOA
	Ensembl ID	ENSG00000189221
	Entrez ID	4128
	Gene name	monoamine oxidase A
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P21397

Top

Dataset with differentially expressed gene: MAOA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.85388	8.24e-12
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.377419	6.53e-16
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.03703	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.338359	1.92e-11

Top

Expression of MAOA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MAOA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
MAOA	Aberration of the Drug's Therapeutic Target

Page: 1

Top

MicroRNAs (miRNA) regulating MAOA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAOA	hsa-miR-7515	92.3249	NM_000240
MAOA	hsa-miR-3059-5p	89.0241	NM_000240
MAOA	hsa-miR-5688	85.4137	NM_000240
MAOA	hsa-miR-4682	84.6531	NM_000240
MAOA	hsa-miR-3680-3p	84.6086	NM_000240
MAOA	hsa-miR-770-5p	84.5054	NM_000240
MAOA	hsa-miR-4712-5p	84.5054	NM_000240
MAOA	hsa-miR-6864-5p	83.392	NM_000240
MAOA	hsa-miR-495-3p	82.8498	NM_000240
MAOA	hsa-miR-1324	80.9372	NM_000240

Page: 1

Top

Motifs and transcription factors (TFs) regulating MAOA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAOA	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
MAOA	taipale_tf_pairs__TEAD4_PITX1_RCATWCNNNNNGGATTA_CAP_repr	PITX1; TEAD4 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MAOA	"4-Methoxyamphetamine"	DB01472	small molecule
MAOA	"Brofaromine"	DB13876	small molecule
MAOA	"Clorgiline"	DB04017	small molecule
MAOA	"CX157"	DB05205	small molecule
MAOA	"Decyl(dimethyl)phosphine oxide"	DB07641	small molecule
MAOA	"Ephedra sinica root"	DB01363	biotech
MAOA	"Flavin adenine dinucleotide"	DB03147	small molecule
MAOA	"Flortaucipir F-18"	DB14914	small molecule
MAOA	"Ginkgo biloba"	DB01381	biotech
MAOA	"Harmine"	DB07919	small molecule
MAOA	"Isocarboxazid"	DB01247	small molecule
MAOA	"Metamfetamine"	DB01577	small molecule
MAOA	"Minaprine"	DB00805	small molecule
MAOA	"MMDA"	DB01442	small molecule
MAOA	"Moclobemide"	DB01171	small molecule
MAOA	"Nialamide"	DB04820	small molecule
MAOA	"Nomifensine"	DB04821	small molecule
MAOA	"Pargyline"	DB01626	small molecule
MAOA	"Phenelzine"	DB00780	small molecule
MAOA	"Phentermine"	DB00191	small molecule
MAOA	"Pirlindole"	DB09244	small molecule
MAOA	"Posizolid"	DB04850	small molecule
MAOA	"Selegiline"	DB01037	small molecule
MAOA	"Toloxatone"	DB09245	small molecule
MAOA	"Tranylcypromine"	DB00752	small molecule
MAOA	"Viloxazine"	DB09185	small molecule
MAOA	"Zimelidine"	DB04832	small molecule
MAOA	"Zonisamide"	DB00909	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."

1	Association of Monoamine Oxidase A with Tumor Burden and Castration Resistance in Prostate Cancer