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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAN1A1

Summary for MAN1A1

Gene information	Gene symbol	MAN1A1
	Ensembl ID	ENSG00000111885
	Entrez ID	4121
	Gene name	mannosidase alpha class 1A member 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P33908

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Dataset with differentially expressed gene: MAN1A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.29482	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.319007	0.00e+00

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Expression of MAN1A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MAN1A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MAN1A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAN1A1	hsa-miR-607	98.2538	NM_005907
MAN1A1	hsa-miR-5011-5p	97.9299	NM_005907
MAN1A1	hsa-miR-651-3p	96.5707	NM_005907
MAN1A1	hsa-miR-190a-3p	96.1107	NM_005907
MAN1A1	hsa-miR-4803	95.867	NM_005907
MAN1A1	hsa-miR-3671	95.2788	NM_005907
MAN1A1	hsa-miR-1468-3p	95.1636	NM_005907
MAN1A1	hsa-miR-548f-5p	94.9463	NM_005907
MAN1A1	hsa-miR-548aj-5p	94.9463	NM_005907
MAN1A1	hsa-miR-548g-5p	94.9463	NM_005907
MAN1A1	hsa-miR-548x-5p	94.9463	NM_005907
MAN1A1	hsa-miR-548c-3p	94.8918	NM_005907
MAN1A1	hsa-miR-4762-5p	93.9718	NM_005907
MAN1A1	hsa-miR-641	92.8166	NM_005907
MAN1A1	hsa-miR-3617-5p	92.8166	NM_005907
MAN1A1	hsa-miR-6516-5p	92.5403	NM_005907
MAN1A1	hsa-miR-340-5p	92.2403	NM_005907
MAN1A1	hsa-miR-548aw	90.7674	NM_005907
MAN1A1	hsa-miR-4456	90.7268	NM_005907
MAN1A1	hsa-miR-520g-3p	90.7018	NM_005907
MAN1A1	hsa-miR-520h	90.7018	NM_005907
MAN1A1	hsa-miR-4470	89.922	NM_005907
MAN1A1	hsa-miR-12122	89.8085	NM_005907
MAN1A1	hsa-miR-1296-3p	89.6062	NM_005907
MAN1A1	hsa-miR-135b-5p	89.5458	NM_005907
MAN1A1	hsa-miR-135a-5p	89.5458	NM_005907
MAN1A1	hsa-miR-4282	89.1968	NM_005907
MAN1A1	hsa-miR-450b-5p	88.7248	NM_005907
MAN1A1	hsa-miR-4495	88.6488	NM_005907
MAN1A1	hsa-miR-513b-5p	88.4494	NM_005907
MAN1A1	hsa-miR-4424	88.3356	NM_005907
MAN1A1	hsa-miR-3658	88.144	NM_005907
MAN1A1	hsa-miR-766-5p	87.6524	NM_005907
MAN1A1	hsa-miR-142-5p	87.3041	NM_005907
MAN1A1	hsa-miR-5590-3p	87.3041	NM_005907
MAN1A1	hsa-miR-302e	87.1406	NM_005907
MAN1A1	hsa-miR-550a-3-5p	87.0429	NM_005907
MAN1A1	hsa-miR-1271-3p	87.0429	NM_005907
MAN1A1	hsa-miR-550a-5p	87.0429	NM_005907
MAN1A1	hsa-miR-3119	86.9547	NM_005907
MAN1A1	hsa-miR-653-5p	85.4714	NM_005907
MAN1A1	hsa-miR-302b-3p	84.9377	NM_005907
MAN1A1	hsa-miR-302c-3p	84.9377	NM_005907
MAN1A1	hsa-miR-302a-3p	84.9377	NM_005907
MAN1A1	hsa-miR-302d-3p	84.9377	NM_005907
MAN1A1	hsa-miR-620	84.9175	NM_005907
MAN1A1	hsa-miR-7515	84.6435	NM_005907
MAN1A1	hsa-miR-8074	84.5854	NM_005907
MAN1A1	hsa-miR-3924	84.3337	NM_005907
MAN1A1	hsa-let-7b-3p	84.0508	NM_005907

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Motifs and transcription factors (TFs) regulating MAN1A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAN1A1	kznf__ZNF273_Imbeault2017_RP_RCADE	ZNF273 (directAnnotation).
MAN1A1	transfac_pro__M01973	PLAG1 (directAnnotation).
MAN1A1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP	ELK1; TBX21 (directAnnotation).
MAN1A1	transfac_public__M00051	NFKB1 (directAnnotation).
MAN1A1	jaspar__MA1522.1	MAZ (directAnnotation).
MAN1A1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
MAN1A1	transfac_pro__M06881	ZNF549 (directAnnotation).
MAN1A1	metacluster_143.13	ZBTB7A (directAnnotation).
MAN1A1	hdpi__PAXIP1	PAXIP1 (directAnnotation).
MAN1A1	transfac_pro__M05845	ZSCAN29 (directAnnotation).
MAN1A1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
MAN1A1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
MAN1A1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
MAN1A1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
MAN1A1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
MAN1A1	metacluster_55.5	ZNF541 (directAnnotation).
MAN1A1	transfac_pro__M04950	EGR1 (directAnnotation).
MAN1A1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
MAN1A1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."