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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MALT1

Summary for MALT1

Gene information	Gene symbol	MALT1
	Ensembl ID	ENSG00000172175
	Entrez ID	10892
	Gene name	MALT1 paracaspase
	Synonyms	MLT\|PCASP1
	Gene type	protein_coding
	UniProtAcc	Q9UDY8

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Dataset with differentially expressed gene: MALT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.294121	0.00e+00

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Expression of MALT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MALT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MALT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MALT1	hsa-miR-190a-3p	99.4888	NM_173844
MALT1	hsa-miR-5011-5p	98.3842	NM_173844
MALT1	hsa-miR-5579-3p	96.8857	NM_173844
MALT1	hsa-miR-6516-5p	94.8995	NM_173844
MALT1	hsa-miR-21-5p	94.0018	NM_173844
MALT1	hsa-let-7b-3p	93.2386	NM_173844
MALT1	hsa-let-7f-1-3p	93.2386	NM_173844
MALT1	hsa-miR-6875-3p	91.6833	NM_173844
MALT1	hsa-miR-4684-5p	91.6097	NM_173844
MALT1	hsa-miR-6867-5p	91.5694	NM_173844
MALT1	hsa-let-7a-3p	91.0129	NM_173844
MALT1	hsa-miR-98-3p	91.0129	NM_173844
MALT1	hsa-miR-590-5p	90.6321	NM_173844
MALT1	hsa-miR-4752	89.2326	NM_173844
MALT1	hsa-miR-3686	86.0243	NM_173844
MALT1	hsa-miR-511-3p	85.9708	NM_173844
MALT1	hsa-miR-627-3p	85.5821	NM_006785
MALT1	hsa-miR-3924	85.5786	NM_173844
MALT1	hsa-miR-4666a-3p	84.3219	NM_173844
MALT1	hsa-miR-1290	83.7884	NM_173844
MALT1	hsa-miR-3659	83.6606	NM_173844
MALT1	hsa-miR-300	83.4186	NM_173844
MALT1	hsa-miR-381-3p	83.4186	NM_173844
MALT1	hsa-miR-5688	82.4364	NM_173844
MALT1	hsa-miR-3182	81.7871	NM_173844
MALT1	hsa-miR-3148	81.5598	NM_173844
MALT1	hsa-miR-6790-5p	81.27	NM_173844
MALT1	hsa-miR-4658	81.27	NM_173844
MALT1	hsa-miR-5579-5p	80.3506	NM_173844

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Motifs and transcription factors (TFs) regulating MALT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MALT1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MALT1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
MALT1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
MALT1	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
MALT1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
MALT1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."