Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MAK16

Summary for MAK16

Gene information	Gene symbol	MAK16
	Ensembl ID	ENSG00000198042
	Entrez ID	84549
	Gene name	MAK16 homolog
	Synonyms	MAK16L\|RBM13
	Gene type	protein_coding
	UniProtAcc	Q9BXY0

Top

Dataset with differentially expressed gene: MAK16

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.391646	2.80e-45

Top

Expression of MAK16 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to MAK16

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating MAK16

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MAK16	hsa-miR-29b-2-5p	97.1326	NM_032509
MAK16	hsa-miR-5693	96.0729	NM_032509
MAK16	hsa-miR-23b-3p	92.6951	NM_032509
MAK16	hsa-miR-23c	92.6951	NM_032509
MAK16	hsa-miR-23a-3p	92.6951	NM_032509
MAK16	hsa-miR-3658	91.3853	NM_032509
MAK16	hsa-miR-6875-3p	90.2002	NM_032509
MAK16	hsa-miR-4282	89.2258	NM_032509
MAK16	hsa-miR-4653-3p	88.8817	NM_032509
MAK16	hsa-miR-6742-3p	88.2973	NM_032509
MAK16	hsa-miR-5000-5p	86.855	NM_032509
MAK16	hsa-miR-548at-5p	86.212	NM_032509
MAK16	hsa-miR-6878-5p	86.092	NM_032509
MAK16	hsa-miR-561-3p	85.5246	NM_032509
MAK16	hsa-miR-5692a	84.5347	NM_032509
MAK16	hsa-miR-214-3p	84.1455	NM_032509
MAK16	hsa-miR-3619-5p	84.1455	NM_032509
MAK16	hsa-miR-3074-3p	83.7301	NM_032509
MAK16	hsa-miR-4799-5p	83.2965	NM_032509
MAK16	hsa-miR-761	82.7759	NM_032509
MAK16	hsa-miR-219a-1-3p	82.7485	NM_032509
MAK16	hsa-miR-4738-3p	82.6901	NM_032509
MAK16	hsa-miR-10526-3p	81.6402	NM_032509
MAK16	hsa-miR-3650	81.2712	NM_032509
MAK16	hsa-miR-6740-5p	81.0562	NM_032509
MAK16	hsa-miR-3611	80.8719	NM_032509
MAK16	hsa-miR-548c-3p	80.2938	NM_032509
MAK16	hsa-miR-1236-3p	80.1696	NM_032509

Page: 1

Top

Motifs and transcription factors (TFs) regulating MAK16

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MAK16	metacluster_135.11	NR2C2 (directAnnotation).
MAK16	cisbp__M00341	PAX6 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."